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- W2856694590 endingPage "580" @default.
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- W2856694590 abstract "The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women." @default.
- W2856694590 created "2018-07-19" @default.
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- W2856694590 date "2018-08-01" @default.
- W2856694590 modified "2023-10-02" @default.
- W2856694590 title "Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition" @default.
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- W2856694590 doi "https://doi.org/10.1016/j.tem.2018.06.001" @default.
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- W2856694590 hasPublicationYear "2018" @default.
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