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• W2885847384 startingPage "1033" @default.
• W2885847384 abstract "Drug-induced liver injury (DILI) remains an increasingly recognized cause of hepatotoxicity and liver failure worldwide. In 2017, we continued to learn about predicting, diagnosing, and prognosticating drug hepatotoxicity. Areas covered: In this review, we selected from over 1200 articles from 2017 to synopsize updates in DILI. There were new HLA haplotypes associated with medications including HLA-C0401 and HLA-B*14. There has been continued work with quantitative systems pharmacology, particularly with the DILIsym® initiative, which employs mathematical representations of DILI mechanisms to predict hepatotoxicity in simulated populations. Additionally, knowledge regarding microRNAs (miRNAs) continues to expand. Some new miRNAs this past year include miRNA-223 and miRNA-605. Aside from miRNAs, other biomarkers for diagnosis, prognosis, and even prediction of DILI were explored. Studies on K18, OPN, and MCSFR have correlated DILI and liver-associated death within 6 months. Conversely, a new prognostic panel using apolipoportein-A1 and haptoglobin has been proposed to predict recovery. Further study of CDH5 has also provided researchers a possible new biomarker for prediction and susceptibility to DILI. Expert commentary: Although research on DILI remains quite promising, there is yet to be a reliable, simple method to predict, diagnose, and risk assess this form of hepatotoxicity." @default.
• W2885847384 created "2018-08-22" @default.
• W2885847384 creator A5018158701 @default.
• W2885847384 creator A5024928696 @default.
• W2885847384 creator A5079409390 @default.
• W2885847384 date "2018-09-03" @default.
• W2885847384 modified "2023-09-26" @default.
• W2885847384 title "Latest advances in diagnosing and predicting DILI: what was new in 2017?" @default.
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• W2885847384 doi "https://doi.org/10.1080/17474124.2018.1512854" @default.
• W2885847384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30111182" @default.
• W2885847384 hasPublicationYear "2018" @default.
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