FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889634264> ?p ?o ?g. }

• W2889634264 endingPage "130" @default.
• W2889634264 startingPage "121" @default.
• W2889634264 abstract "The glycocalyx is a layer of glycoproteins, proteoglycans and glycosaminoglycans that coats the luminal surface of most blood vessels. It effectively regulates adhesive interactions between leukocytes in flowing blood and the endothelium, where during inflammation, binding to E- and P-selectins and intercellular adhesion molecule-1 (ICAM-1) promotes cell tethering and arrest under shear flow.In this study, we examine the targeting of E-selectin by an engineered peptide moiety bound to a dermatan sulfate backbone. We further investigate this conjugate, denoted as EC-SEAL, by observing its binding to inflamed endothelium, and quantifying its ability to modulate neutrophil-endothelium interactions.Binding data reveal that EC-SEAL recognizes domains on E-selectin, and to a lesser degree on P- and L-selectin, and ICAM-1. Further, EC-SEAL increases neutrophil rolling velocity, and decreases neutrophil arrest and migration on inflamed human microvascular endothelial cells under physiologically relevant flow conditions.We conclude that simple targeting strategies can mimic glycocalyx function under inflammatory conditions, effectively reducing neutrophil recruitment." @default.
• W2889634264 created "2018-09-27" @default.
• W2889634264 creator A5019384731 @default.
• W2889634264 creator A5052913120 @default.
• W2889634264 creator A5054772078 @default.
• W2889634264 creator A5058961454 @default.
• W2889634264 creator A5085637012 @default.
• W2889634264 date "2018-09-17" @default.
• W2889634264 modified "2023-10-11" @default.
• W2889634264 title "Selectin-Targeting Peptide–Glycosaminoglycan Conjugates Modulate Neutrophil–Endothelial Interactions" @default.
• W2889634264 cites W1600560134 @default.
• W2889634264 cites W1981478009 @default.
• W2889634264 cites W1986628114 @default.
• W2889634264 cites W1998915656 @default.
• W2889634264 cites W2002253618 @default.
• W2889634264 cites W2032227357 @default.
• W2889634264 cites W2060228585 @default.
• W2889634264 cites W2062023215 @default.
• W2889634264 cites W2062995790 @default.
• W2889634264 cites W2066454958 @default.
• W2889634264 cites W2083311984 @default.
• W2889634264 cites W2100869552 @default.
• W2889634264 cites W2104723371 @default.
• W2889634264 cites W2105074740 @default.
• W2889634264 cites W2111766323 @default.
• W2889634264 cites W2116999983 @default.
• W2889634264 cites W2127715753 @default.
• W2889634264 cites W2131545125 @default.
• W2889634264 cites W2157453847 @default.
• W2889634264 cites W2158375930 @default.
• W2889634264 cites W2164957007 @default.
• W2889634264 cites W2165465995 @default.
• W2889634264 cites W2169864898 @default.
• W2889634264 cites W2272074586 @default.
• W2889634264 cites W2398375166 @default.
• W2889634264 cites W2599489435 @default.
• W2889634264 cites W2739174192 @default.
• W2889634264 cites W4246950174 @default.
• W2889634264 doi "https://doi.org/10.1007/s12195-018-0555-6" @default.
• W2889634264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6345733" @default.
• W2889634264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30740185" @default.
• W2889634264 hasPublicationYear "2018" @default.
• W2889634264 type Work @default.
• W2889634264 sameAs 2889634264 @default.
• W2889634264 citedByCount "9" @default.
• W2889634264 countsByYear W28896342642020 @default.
• W2889634264 countsByYear W28896342642021 @default.
• W2889634264 countsByYear W28896342642022 @default.
• W2889634264 countsByYear W28896342642023 @default.
• W2889634264 crossrefType "journal-article" @default.
• W2889634264 hasAuthorship W2889634264A5019384731 @default.
• W2889634264 hasAuthorship W2889634264A5052913120 @default.
• W2889634264 hasAuthorship W2889634264A5054772078 @default.
• W2889634264 hasAuthorship W2889634264A5058961454 @default.
• W2889634264 hasAuthorship W2889634264A5085637012 @default.
• W2889634264 hasBestOaLocation W28896342641 @default.
• W2889634264 hasConcept C108625454 @default.
• W2889634264 hasConcept C134018914 @default.
• W2889634264 hasConcept C1491633281 @default.
• W2889634264 hasConcept C153074725 @default.
• W2889634264 hasConcept C155619193 @default.
• W2889634264 hasConcept C16224149 @default.
• W2889634264 hasConcept C185592680 @default.
• W2889634264 hasConcept C203014093 @default.
• W2889634264 hasConcept C2776914184 @default.
• W2889634264 hasConcept C2776992346 @default.
• W2889634264 hasConcept C2780098789 @default.
• W2889634264 hasConcept C3018697912 @default.
• W2889634264 hasConcept C55493867 @default.
• W2889634264 hasConcept C56701166 @default.
• W2889634264 hasConcept C85789140 @default.
• W2889634264 hasConcept C86803240 @default.
• W2889634264 hasConcept C89560881 @default.
• W2889634264 hasConcept C95444343 @default.
• W2889634264 hasConceptScore W2889634264C108625454 @default.
• W2889634264 hasConceptScore W2889634264C134018914 @default.
• W2889634264 hasConceptScore W2889634264C1491633281 @default.
• W2889634264 hasConceptScore W2889634264C153074725 @default.
• W2889634264 hasConceptScore W2889634264C155619193 @default.
• W2889634264 hasConceptScore W2889634264C16224149 @default.
• W2889634264 hasConceptScore W2889634264C185592680 @default.
• W2889634264 hasConceptScore W2889634264C203014093 @default.
• W2889634264 hasConceptScore W2889634264C2776914184 @default.
• W2889634264 hasConceptScore W2889634264C2776992346 @default.
• W2889634264 hasConceptScore W2889634264C2780098789 @default.
• W2889634264 hasConceptScore W2889634264C3018697912 @default.
• W2889634264 hasConceptScore W2889634264C55493867 @default.
• W2889634264 hasConceptScore W2889634264C56701166 @default.
• W2889634264 hasConceptScore W2889634264C85789140 @default.
• W2889634264 hasConceptScore W2889634264C86803240 @default.
• W2889634264 hasConceptScore W2889634264C89560881 @default.
• W2889634264 hasConceptScore W2889634264C95444343 @default.
• W2889634264 hasFunder F4320332161 @default.
• W2889634264 hasIssue "1" @default.
• W2889634264 hasLocation W28896342641 @default.
• W2889634264 hasLocation W28896342642 @default.
• W2889634264 hasLocation W28896342643 @default.
• W2889634264 hasLocation W28896342644 @default.

• next