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• W2890179149 abstract "We evaluated the effects of rifampin coadministration and MDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in the clearance (0.53 versus 0.55 liters/h, P = 1.00), volume of distribution (7.0 versus 7.2 liter, P = 0.62), or half-life (9.7 versus 9.6 h, P = 0.89) of daptomycin after exposure to rifampin. The tested MDR1 polymorphisms were not associated with significant differences in daptomycin disposition." @default.
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• W2890179149 date "2018-12-01" @default.
• W2890179149 modified "2023-09-27" @default.
• W2890179149 title "Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers" @default.
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• W2890179149 doi "https://doi.org/10.1128/aac.01525-18" @default.
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