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- W2891216113 abstract "Aurora B is aberrantly expressed in various tumors and shown to be a promising target for cancer therapy. Butein, a chalcone isolated from Rhus cerniciflua, has demonstrated antitumor activities in different cancers. In this study, we aimed to validate whether Aurora B kinase was the direct target of butein to exhibit its potency in hepatocellular carcinoma (HCC). Comparing with the normal cell line and tissue, Aurora B was overexpressed in all tested HCC cells and the majority of tumor tissue. Knocking down of Aurora B with shRNA substantially inhibited HCC cell proliferation, colony formation and delayed tumor growth in nude mice. Except computer docking, a series of kinase assays revealed butein directly interacted with Aurora B and inhibited its kinase activity. Along with the decrease of Aurora B and histone H3 phosphorylation, HCC cells were induced G2/M cell cycle arrest and subjected to cell apoptosis. Butein-mediated antitumor activities were substantially impaired in Aurora B knockdown cells, suggesting Aurora B was an important target of butein in HCC. Oral administration of butein substantially restrained HCC xenograft growth and the expressions of Ki67 and phosphor-histone H3 were significantly decreased in butein-treated tissue. To the best of our knowledge, our studies revealed that Aurora B was the direct target of butein in HCC." @default.
- W2891216113 created "2018-09-27" @default.
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- W2891216113 date "2018-01-01" @default.
- W2891216113 modified "2023-10-17" @default.
- W2891216113 title "Butein suppresses hepatocellular carcinoma growth via modulating Aurora B kinase activity" @default.
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- W2891216113 doi "https://doi.org/10.7150/ijbs.25334" @default.
- W2891216113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158728" @default.
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