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- W2894708698 abstract "Introduction: Gallbladder cancer remains a diagnostic dilemma among patients presenting with gallbladder mass lesion. The value of inflammatory markers in differentiating between benign and malignant lesions have been reportedly found to be equivocal. We aim to investigate the value of inflammatory markers in patients presenting gallbladder mass lesions. Methods: All of the patients presenting to our institution with suspicious gallbladder lesions from January 2011 to December 2017 were reviewed. Patients with confirmed histopathology. Inflammatory markers included Neutrophil/Lymphocyte ratio (NLR) and Platelet/Lymphocyte ratio (PLR) were collected for all patients. The data was analyzed by Spearman correlation and Wilcoxon rank-sum test. Results: A total of 81 patients were identified with apprehensive gallbladder lesions. 76 patients had confirmed histopathology and recorded neutrophils, lymphocytes and platelets count at the time of diagnosis. [35 (46%) gallbladder cancer, and 41 (54%) gallbladder inflammatory conditions]. The mean NLR for malignant lesions was 3.8 (95% CI: 2.5 - 5.0) and for the benign lesions was 2.8 (95% CI: 2.1 - 3.6). The difference between the NLR values showed high trend but the P value is not statistically significant (0.06). The mean PLR for malignant lesions was 192.0 (95% CI: 143.4 - 240.7) and for the benign lesions was 149.4 (95% CI: 117.0 - 181.9). The difference was not significant (P value: 0.12). Conclusion: We found that inflammatory markers; namely the NLR, may be helpful as a surrogate marker in the diagnosis of gallbladder cancer; however larger sample sized studies may be useful in depicting the significant difference." @default.
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- W2894708698 date "2018-09-01" @default.
- W2894708698 modified "2023-10-15" @default.
- W2894708698 title "Suspicious gallbladder masses; the value of inflammatory markers in depicting gallbladder cancer" @default.
- W2894708698 doi "https://doi.org/10.1016/j.hpb.2018.06.1427" @default.
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