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- W2896008418 endingPage "557" @default.
- W2896008418 startingPage "537" @default.
- W2896008418 abstract "Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is a well-established mediator of atherosclerosis and a key target for intervention for the primary and secondary prevention of ASCVD. However, despite substantial reduction in LDL-C, patients continue to have recurrent ASCVD events. Hypertriglyceridemia may be an important contributor of this residual risk. Observational and genetic epidemiological data strongly support a causal role of triglycerides (TGs) and the cholesterol content within triglyceride-rich lipoproteins (TGRLs) and/or remnant cholesterol (RC) in the development of ASCVD. TGRLs are composed of hepatically derived very low-density lipoprotein and intestinally derived chylomicrons. RC is the cholesterol content of all TGRLs and plasma TGs serve as a surrogate measure of TGRLs and RC. Although lifestyle modification remains the cornerstone for management of hypertriglyceridemia, many novel drugs are in development and have shown impressive efficacy in lowering TG levels. Several ongoing, randomized controlled trials are underway to examine the impact of these novel agents on ASCVD outcomes. In this comprehensive review, we provide an overview of the biology, epidemiology, and genetics of TGs and ASCVD; we discuss current and novel TG-lowering therapies under development." @default.
- W2896008418 created "2018-10-26" @default.
- W2896008418 creator A5010041931 @default.
- W2896008418 creator A5022083191 @default.
- W2896008418 creator A5067797353 @default.
- W2896008418 creator A5076589993 @default.
- W2896008418 date "2018-10-11" @default.
- W2896008418 modified "2023-10-17" @default.
- W2896008418 title "The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk" @default.
- W2896008418 cites W1275357281 @default.
- W2896008418 cites W1510072729 @default.
- W2896008418 cites W1519335354 @default.
- W2896008418 cites W1607804102 @default.
- W2896008418 cites W1918267826 @default.
- W2896008418 cites W1918701009 @default.
- W2896008418 cites W1959291640 @default.
- W2896008418 cites W1960566546 @default.
- W2896008418 cites W1969927159 @default.
- W2896008418 cites W1974471798 @default.
- W2896008418 cites W1975018096 @default.
- W2896008418 cites W1976428272 @default.
- W2896008418 cites W1977335231 @default.
- W2896008418 cites W1981499442 @default.
- W2896008418 cites W1982040758 @default.
- W2896008418 cites W1984259997 @default.
- W2896008418 cites W1989589017 @default.
- W2896008418 cites W1990953214 @default.
- W2896008418 cites W1996751500 @default.
- W2896008418 cites W2005157832 @default.
- W2896008418 cites W2006551863 @default.
- W2896008418 cites W2007576400 @default.
- W2896008418 cites W2007582789 @default.
- W2896008418 cites W2007746673 @default.
- W2896008418 cites W2011468836 @default.
- W2896008418 cites W2013299898 @default.
- W2896008418 cites W2019071303 @default.
- W2896008418 cites W2019818397 @default.
- W2896008418 cites W2020249340 @default.
- W2896008418 cites W2020915011 @default.
- W2896008418 cites W2023555072 @default.
- W2896008418 cites W2026825032 @default.
- W2896008418 cites W2032456325 @default.
- W2896008418 cites W2036747551 @default.
- W2896008418 cites W2037407219 @default.
- W2896008418 cites W2038477308 @default.
- W2896008418 cites W2038708549 @default.
- W2896008418 cites W2040770080 @default.
- W2896008418 cites W2041380076 @default.
- W2896008418 cites W2042140336 @default.
- W2896008418 cites W2042869855 @default.
- W2896008418 cites W2045868118 @default.
- W2896008418 cites W2046449500 @default.
- W2896008418 cites W2048070048 @default.
- W2896008418 cites W2048760408 @default.
- W2896008418 cites W2049135972 @default.
- W2896008418 cites W2050838276 @default.
- W2896008418 cites W2052341239 @default.
- W2896008418 cites W2052644460 @default.
- W2896008418 cites W2052740563 @default.
- W2896008418 cites W2054299101 @default.
- W2896008418 cites W2060719440 @default.
- W2896008418 cites W2061100095 @default.
- W2896008418 cites W2067539811 @default.
- W2896008418 cites W2069898248 @default.
- W2896008418 cites W2077244492 @default.
- W2896008418 cites W2077247955 @default.
- W2896008418 cites W2079274944 @default.
- W2896008418 cites W2079979713 @default.
- W2896008418 cites W2079994876 @default.
- W2896008418 cites W2080036080 @default.
- W2896008418 cites W2084878337 @default.
- W2896008418 cites W2085523397 @default.
- W2896008418 cites W2086785365 @default.
- W2896008418 cites W2089666854 @default.
- W2896008418 cites W2095768296 @default.
- W2896008418 cites W2096210401 @default.
- W2896008418 cites W2099767767 @default.
- W2896008418 cites W2101328789 @default.
- W2896008418 cites W2101864445 @default.
- W2896008418 cites W2106937178 @default.
- W2896008418 cites W2107665972 @default.
- W2896008418 cites W2108169164 @default.
- W2896008418 cites W2108483230 @default.
- W2896008418 cites W2109095803 @default.
- W2896008418 cites W2111099202 @default.
- W2896008418 cites W2111416524 @default.
- W2896008418 cites W2112221135 @default.
- W2896008418 cites W2112710165 @default.
- W2896008418 cites W2113638285 @default.
- W2896008418 cites W2113680815 @default.
- W2896008418 cites W2115509231 @default.
- W2896008418 cites W2117092539 @default.
- W2896008418 cites W2118825330 @default.
- W2896008418 cites W2119138136 @default.
- W2896008418 cites W2121568629 @default.
- W2896008418 cites W2124450273 @default.
- W2896008418 cites W2124481954 @default.
- W2896008418 cites W2125012558 @default.