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- W2898514238 abstract "Introduction: Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery pressures and pulmonary vascular resistance. As no definitive treatment options exist, and lung transplant also carries significant mortality rates, optimizing treatment strategies and timing for transplant remains crucial; a quantitative measure to predict disease progression would be greatly beneficial in treatment planning. Hypothesis: We hypothesize that right ventricular (RV) stroke work correlates with clinical worsening in PAH patients. Methods: Pediatric patients (<18 years) with idiopathic PAH or PAH secondary to congenital heart diseases with serial, matched catheterization and magnetic resonance imaging (MRI) data were included. RV and PA hemodynamics were numerically simulated by a lumped parameter (circuit analogy) model to create patient-specific pressure-volume (PV) loops not easily replicated clinically. The model was tuned using optimization techniques to match patient-specific MRI and cath-d..." @default.
- W2898514238 created "2018-11-02" @default.
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- W2898514238 date "2016-11-11" @default.
- W2898514238 modified "2023-09-28" @default.
- W2898514238 title "Abstract 20168: Right Ventricular Stroke Work Correlates With Outcomes in Pediatric Pulmonary Arterial Hypertension (PAH) Patients" @default.
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