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- W2900141214 abstract "Hyperglycemia invoke number of pathways resulting in development of diabetic retinopathy (DR), including protein kinase C activation, increased expression of VEGF, advanced glycation end product (AGEs) formation and activation of polyol pathway, among which the pathophysiology of aldose reductase (ALR2) of the polyol pathway is evident by more than a decade of research. Subtle involvement of ALR2 in invoking various pathways of diabetic complications has caused an increase in attention towards the identification of novel aldose reductase inhibitors (ARIs). Numerous ARIs of different classes were employed in the treatment of diabetic complications initially, but few came into light as drugs. Though no ALR2 inhibitor has been used for the treatment or control of DR, Epalrestat has been used worldwide for treating diabetic neuropathy. This review critically analyses different treatments available for diabetic retinopathy, their limitations and the importance of the development of novel inhibitors of ALR2 that could prevent progression of DR, by causing a direct or indirect effect on controlling factors associated with DR." @default.
- W2900141214 created "2018-11-16" @default.
- W2900141214 creator A5034306073 @default.
- W2900141214 creator A5064860579 @default.
- W2900141214 date "2019-01-01" @default.
- W2900141214 modified "2023-09-30" @default.
- W2900141214 title "A non-invasive, multi-target approach to treat diabetic retinopathy" @default.
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- W2900141214 cites W1554587971 @default.
- W2900141214 cites W1594529249 @default.
- W2900141214 cites W1822662507 @default.
- W2900141214 cites W1964518694 @default.
- W2900141214 cites W1965563034 @default.
- W2900141214 cites W1966662116 @default.
- W2900141214 cites W1968415431 @default.
- W2900141214 cites W1969453607 @default.
- W2900141214 cites W1975118631 @default.
- W2900141214 cites W1977323463 @default.
- W2900141214 cites W1983943345 @default.
- W2900141214 cites W1986014108 @default.
- W2900141214 cites W1988094320 @default.
- W2900141214 cites W1988143227 @default.
- W2900141214 cites W1988561985 @default.
- W2900141214 cites W1988635561 @default.
- W2900141214 cites W1992451339 @default.
- W2900141214 cites W1993628563 @default.
- W2900141214 cites W1996337164 @default.
- W2900141214 cites W2001990540 @default.
- W2900141214 cites W2012564902 @default.
- W2900141214 cites W2016795705 @default.
- W2900141214 cites W2018516156 @default.
- W2900141214 cites W2026480246 @default.
- W2900141214 cites W2028212562 @default.
- W2900141214 cites W2032274607 @default.
- W2900141214 cites W2034035188 @default.
- W2900141214 cites W2035182977 @default.
- W2900141214 cites W2037722239 @default.
- W2900141214 cites W2039120010 @default.
- W2900141214 cites W2039243216 @default.
- W2900141214 cites W2045906766 @default.
- W2900141214 cites W2048599732 @default.
- W2900141214 cites W2048700739 @default.
- W2900141214 cites W2059982425 @default.
- W2900141214 cites W2066746672 @default.
- W2900141214 cites W2073688567 @default.
- W2900141214 cites W2076908539 @default.
- W2900141214 cites W2083732465 @default.
- W2900141214 cites W2084691395 @default.
- W2900141214 cites W2086626477 @default.
- W2900141214 cites W2093470897 @default.
- W2900141214 cites W2094822452 @default.
- W2900141214 cites W2098692284 @default.
- W2900141214 cites W2099930528 @default.
- W2900141214 cites W2102465598 @default.
- W2900141214 cites W2102939844 @default.
- W2900141214 cites W2105731956 @default.
- W2900141214 cites W2106096187 @default.
- W2900141214 cites W2107066255 @default.
- W2900141214 cites W2109142150 @default.
- W2900141214 cites W2113265909 @default.
- W2900141214 cites W2115232314 @default.
- W2900141214 cites W2122883407 @default.
- W2900141214 cites W2126946832 @default.
- W2900141214 cites W2130249562 @default.
- W2900141214 cites W2137631271 @default.
- W2900141214 cites W2143651350 @default.
- W2900141214 cites W2148736743 @default.
- W2900141214 cites W2152772099 @default.
- W2900141214 cites W2154893083 @default.
- W2900141214 cites W2156847451 @default.
- W2900141214 cites W2160907352 @default.
- W2900141214 cites W2161687494 @default.
- W2900141214 cites W2161727220 @default.
- W2900141214 cites W2163029824 @default.
- W2900141214 cites W2255915114 @default.
- W2900141214 cites W2288699911 @default.
- W2900141214 cites W2298712327 @default.
- W2900141214 cites W2316516002 @default.
- W2900141214 cites W2346484181 @default.
- W2900141214 cites W2560124981 @default.
- W2900141214 cites W2765849199 @default.
- W2900141214 cites W2783820320 @default.
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- W2900141214 doi "https://doi.org/10.1016/j.biopha.2018.10.185" @default.
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- W2900141214 hasPublicationYear "2019" @default.
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