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- W2904204857 abstract "The maintenance of homeostasis in rumen epithelium has an essential role in the protection by increasing rumen acidity and endotoxin produced from the resident microbiota. However, this system is continuously changed by an enormous microbial load, a high degree of microbial diversity, a vast surface area and frequent challenges from pathogenic microorganisms. Subacute ruminal acidosis (SARA) is the well-recognized metabolic disorders along with fatty liver, ketosis and abomasal displacement. Rumen wall damages in cattle with SARA allows microbes and endotoxin to enter host. Using RNA-sequence analysis, we previously identified the cytokines and chemokines changed in rumen papillae from suckling (5 wks old) and weaned (15 wks old) Japanese Black calves. Whereas its role and its target receptors in rumen papillae are unknown, these chemokines may be involved in mononuclear cells and macrophages recruitment to inflammatory sites by binding to the G-protein-coupled receptors CCR1, CCR3, and CCR5. This study was investigated the expression of CCL5 and its receptors in rumen papillae, and the possible functional roles between the factors derived from rumen microbe and epithelium. The mRNA expression of CCL5 in rumen papillae of weaned calves fed with concentrated diet was higher than milk-fed calves. The mRNA expression of CCR5, one of CCL5 receptor, was tended to be higher in rumen papillae pf weaned calves compared with milk-fed calves. There were no differences in other receptors between both groups. CCL5 in rumen papillae was localized in the epithelium, especially in basal and spinous layer. The expression of TLR5 gene was higher in rumen papillae of milk-fed calves, and mRNA expression of TLR4 was lower in rumen tissue of weaned calves. These results indicate that CCL5 might be one of the key player in immune system of rumen and TLR5-CCL5-receptor axis might be existed in rumen to react against antigen during weaning." @default.
- W2904204857 created "2018-12-22" @default.
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- W2904204857 date "2018-12-01" @default.
- W2904204857 modified "2023-09-27" @default.
- W2904204857 title "16 The control of homeostasis in rumen epithelium of Japanese Black cattle." @default.
- W2904204857 doi "https://doi.org/10.1093/jas/sky404.001" @default.
- W2904204857 hasPublicationYear "2018" @default.
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