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- W2904255878 abstract "The Hokkaido Study on Environment and Children’s Health is an ongoing study of two birth cohorts: the Sapporo cohort and the Hokkaido cohort. Our primary goals are (1) to examine the possible effects of low-level environmental chemical exposures, (2) to follow childhood development through a longitudinal observation study, (3) to identify a high-risk group classified by genetic susceptibility, and (4) to identify any additive effects. Maternal and cord blood were collected for an environmental chemical exposure assessment of dioxins, polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances, phthalates, bisphenol A, and methylmercury. Assessments of health outcomes regarding birth size, neurodevelopment, asthma, allergies and infectious diseases, and hormone levels were conducted, along with observation of the children’s growth. Both genetic and epigenetic analyses were also conducted to examine the effects of environmental chemical exposures on a genetically susceptible population and on DNA methylation. Our study suggests that prenatal environmental chemical exposure affects birth size, hormone balance, neurodevelopment, and immune function, even at relatively low levels. Furthermore, specific genotypes may modify the effects of chemical exposure on health outcomes. Epigenetics, such as DNA methylation, may explain in part the mechanism of action." @default.
- W2904255878 created "2018-12-22" @default.
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- W2904255878 date "2018-12-11" @default.
- W2904255878 modified "2023-09-25" @default.
- W2904255878 title "The Hokkaido Study on Environment and Children’s Health" @default.
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- W2904255878 doi "https://doi.org/10.1007/978-981-13-2194-8_9" @default.
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