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• W2906509330 startingPage "69" @default.
• W2906509330 abstract "Naturally-derived polysaccharides, such as alginate and chitosan, can be assembled to form nanocarriers for the delivery of therapeutic agents. Here we exploit the electrostatic complexation of alginate/chitosan in a water-in-oil (w/o) emulsion process to produce doxorubicin (DOX)-loaded nanoparticles (~80 nm) with exceptional spherical morphology and uniformity. This robust synthetic route utilizes an aqueous phase dispersed in a cyclohexane/dodecylamine organic phase and is capable of encapsulating DOX in the nanoparticle solution. The uptake and efficacy of this novel formulation was evaluated in a murine breast cancer cell line, 4T1, with comparable 72 h IC50 values of the nanoparticle solution (0.15 μg/mL) and free DOX (0.13 μg/mL). Overall, the favorable performance, physiochemical properties, and their facile production support these nanocarriers as promising platform for the delivery of aqueous soluble drugs." @default.
• W2906509330 created "2019-01-01" @default.
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• W2906509330 date "2019-01-01" @default.
• W2906509330 modified "2023-09-24" @default.
• W2906509330 title "Inverse-Micelle Synthesis of Doxorubicin-Loaded Alginate/Chitosan Nanoparticles and In Vitro Assessment of Breast Cancer Cytotoxicity" @default.
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• W2906509330 doi "https://doi.org/10.1016/j.colcom.2018.12.002" @default.
• W2906509330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6786499" @default.
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• W2906509330 hasPublicationYear "2019" @default.
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