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- W2907172978 abstract "While combination antiretroviral therapies (cART) have transformed HIV infection into a chronic manageable condition, they do not act upon the latent HIV reservoir and are therefore not curative. As HIV cure or remission should be more readily achievable in individuals with smaller HIV reservoirs, achieving a deeper understanding of the clinical, immunological, and virological determinants of reservoir size is critical to eradication efforts. We performed a post hoc analysis of 30 participants of a clinical trial of early cART who had previously been assessed in detail for their clinical, immunological, and reservoir size characteristics. We observed that the HIV subtype and autologous Nef-mediated HLA downregulation function correlated with the viral reservoir size measured approximately 1 year post-cART initiation. Our findings highlight virological characteristics—both genetic and functional—as possible novel determinants of HIV reservoir establishment and persistence." @default.
- W2907172978 created "2019-01-11" @default.
- W2907172978 creator A5002192906 @default.
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- W2907172978 creator A5088462680 @default.
- W2907172978 date "2019-03-15" @default.
- W2907172978 modified "2023-10-13" @default.
- W2907172978 title "HIV Subtype and Nef-Mediated Immune Evasion Function Correlate with Viral Reservoir Size in Early-Treated Individuals" @default.
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- W2907172978 doi "https://doi.org/10.1128/jvi.01832-18" @default.