FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2913554612> ?p ?o ?g. }

• W2913554612 endingPage "3219" @default.
• W2913554612 startingPage "3210" @default.
• W2913554612 abstract "Abstract Over the last several years, several molecular aberrations have been unevenly described across cancers, although the distinct functional relevance in each biological context is not yet fully understood. Novel discoveries have led to the development of drugs tailored to the molecular profile of patients, thus increasing the likelihood of response among biomarker-selected patients. In this context, there has been a progressive redefinition of a precision medicine framework where evidence-based development and earlier approvals might now be driven by this molecular information. Innovative trial designs have greatly facilitated the evaluation and approval of new drugs in small cohorts of orphan cancers in which histology-dependent molecularly defined trials might be logistically difficult. However, accelerated approvals based on this agnostic-histology development model have brought new clinical, regulatory, and reimbursement challenges. In this article, we will highlight many of the biologic issues and clinical trial design challenges characterizing the development of tissue-agnostic compounds. Also, we will review some of the key factors involved in the development of pembrolizumab and larotrectinib, the first two drugs that have been approved by the U.S. Food and Drug Administration in an histology-agnostic manner. Because we anticipate that agnostic-histology approvals will continue to grow, we aim to provide insight into the current panorama of targeted drugs that are following this strategy and some premises to take into consideration. Clinicians and regulators should be prepared to overcome the associated potential hurdles, ensuring that uncertainties are dealt with properly and allowing new, promising agents to arrive faster to the market." @default.
• W2913554612 created "2019-02-21" @default.
• W2913554612 creator A5013760636 @default.
• W2913554612 creator A5025563724 @default.
• W2913554612 creator A5058642751 @default.
• W2913554612 creator A5075296860 @default.
• W2913554612 creator A5076983415 @default.
• W2913554612 date "2019-06-01" @default.
• W2913554612 modified "2023-10-18" @default.
• W2913554612 title "Agnostic-Histology Approval of New Drugs in Oncology: Are We Already There?" @default.
• W2913554612 cites W1663153674 @default.
• W2913554612 cites W1759669640 @default.
• W2913554612 cites W1782443628 @default.
• W2913554612 cites W1846586690 @default.
• W2913554612 cites W1940241680 @default.
• W2913554612 cites W2000770117 @default.
• W2913554612 cites W2011458181 @default.
• W2913554612 cites W2014881369 @default.
• W2913554612 cites W2049553585 @default.
• W2913554612 cites W2053843014 @default.
• W2913554612 cites W2096387850 @default.
• W2913554612 cites W2100439220 @default.
• W2913554612 cites W2104885590 @default.
• W2913554612 cites W2106543129 @default.
• W2913554612 cites W2110682589 @default.
• W2913554612 cites W2134119471 @default.
• W2913554612 cites W2136919572 @default.
• W2913554612 cites W2152454229 @default.
• W2913554612 cites W2160088281 @default.
• W2913554612 cites W2303158491 @default.
• W2913554612 cites W2318605753 @default.
• W2913554612 cites W2336815607 @default.
• W2913554612 cites W2345415641 @default.
• W2913554612 cites W2347070489 @default.
• W2913554612 cites W2508622625 @default.
• W2913554612 cites W2514946118 @default.
• W2913554612 cites W2529308344 @default.
• W2913554612 cites W2555408488 @default.
• W2913554612 cites W2567691834 @default.
• W2913554612 cites W2570159314 @default.
• W2913554612 cites W2592465655 @default.
• W2913554612 cites W2603483649 @default.
• W2913554612 cites W2612419201 @default.
• W2913554612 cites W2619545114 @default.
• W2913554612 cites W2620626563 @default.
• W2913554612 cites W2622499649 @default.
• W2913554612 cites W2671996661 @default.
• W2913554612 cites W2726405642 @default.
• W2913554612 cites W2761551369 @default.
• W2913554612 cites W2763176328 @default.
• W2913554612 cites W2763584377 @default.
• W2913554612 cites W2767857925 @default.
• W2913554612 cites W2776050384 @default.
• W2913554612 cites W2776526327 @default.
• W2913554612 cites W2783528963 @default.
• W2913554612 cites W2785610956 @default.
• W2913554612 cites W2790254562 @default.
• W2913554612 cites W2791308824 @default.
• W2913554612 cites W2791410762 @default.
• W2913554612 cites W2792189225 @default.
• W2913554612 cites W2793126529 @default.
• W2913554612 cites W2794052642 @default.
• W2913554612 cites W2796292093 @default.
• W2913554612 cites W2797098362 @default.
• W2913554612 cites W2797675588 @default.
• W2913554612 cites W2806006952 @default.
• W2913554612 cites W2807529598 @default.
• W2913554612 cites W2808043435 @default.
• W2913554612 cites W2810456709 @default.
• W2913554612 cites W2810893606 @default.
• W2913554612 cites W2885589810 @default.
• W2913554612 cites W2885875860 @default.
• W2913554612 cites W2886187034 @default.
• W2913554612 cites W2886963239 @default.
• W2913554612 cites W2888034354 @default.
• W2913554612 cites W2890812992 @default.
• W2913554612 cites W2892152835 @default.
• W2913554612 cites W2892311857 @default.
• W2913554612 cites W2897839972 @default.
• W2913554612 doi "https://doi.org/10.1158/1078-0432.ccr-18-3694" @default.
• W2913554612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30670489" @default.
• W2913554612 hasPublicationYear "2019" @default.
• W2913554612 type Work @default.
• W2913554612 sameAs 2913554612 @default.
• W2913554612 citedByCount "28" @default.
• W2913554612 countsByYear W29135546122019 @default.
• W2913554612 countsByYear W29135546122020 @default.
• W2913554612 countsByYear W29135546122021 @default.
• W2913554612 countsByYear W29135546122022 @default.
• W2913554612 countsByYear W29135546122023 @default.
• W2913554612 crossrefType "journal-article" @default.
• W2913554612 hasAuthorship W2913554612A5013760636 @default.
• W2913554612 hasAuthorship W2913554612A5025563724 @default.
• W2913554612 hasAuthorship W2913554612A5058642751 @default.
• W2913554612 hasAuthorship W2913554612A5075296860 @default.
• W2913554612 hasAuthorship W2913554612A5076983415 @default.
• W2913554612 hasBestOaLocation W29135546121 @default.
• W2913554612 hasConcept C142724271 @default.

• next