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- W2915202043 abstract "Adipocytes play a central role in energy balance, and dysfunctional adipose tissue severely affects systemic energy homeostasis. The ATPase EH domain-containing 2 (EHD2) has previously been shown to regulate caveolae, plasma membrane-specific domains that are involved in lipid uptake and signal transduction. Here, we investigated the role of EHD2 in adipocyte function. We demonstrate that EHD2 protein expression is highly up-regulated at the onset of triglyceride accumulation during adipocyte differentiation. Small interfering RNA-mediated EHD2 silencing affected the differentiation process and impaired insulin sensitivity, lipid storage capacity, and lipolysis. Fluorescence imaging revealed localization of EHD2 to caveolae, close to cell surface-associated lipid droplets in primary human adipocytes. These lipid droplets stained positive for glycerol transporter aquaporin 7 and phosphorylated perilipin-1 following adrenergic stimulation. Further, EHD2 overexpression in human adipocytes increased the lipolytic signaling and suppressed the activity of transcription factor PPARγ. Overall, these data suggest that EHD2 plays a key role for adipocyte function." @default.
- W2915202043 created "2019-03-02" @default.
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- W2915202043 date "2019-05-01" @default.
- W2915202043 modified "2023-09-27" @default.
- W2915202043 title "EHD2 regulates adipocyte function and is enriched at cell surface–associated lipid droplets in primary human adipocytes" @default.
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- W2915202043 doi "https://doi.org/10.1091/mbc.e18-10-0680" @default.
- W2915202043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6724522" @default.
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