FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916466206> ?p ?o ?g. }

• W2916466206 endingPage "108691" @default.
• W2916466206 startingPage "108691" @default.
• W2916466206 abstract "Galangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to its poor aqueous solubility, P-gp efflux and rapid in vivo metabolism by cytochrome enzymes. In order to address the drawbacks of galangin, the current work was designed with an objective to prepare liver targeted galangin loaded galactosylated pluronic F68 polymeric (GF68-Gal) micelles. Galactosylated pluronic F68 copolymer was successfully synthesized usi reduction amination method and used for micelle preparation. The prepared micelles were evaluated for micelle size, entrapment efficiency, zeta potential, in vitro galangin release and in vivo biodistribution. The average size of GF68-Gal micelles was found to be around 242±4.6 nm with an entrapment efficiency of about 77.5± 0.34% w/w. In vitro dissolution profile of GF68-Gal micelles revealed controlled release of galangin. Further, biodistribution studies of GF68-Gal micelles showed significant improvement in the amount of galangin in liver at 15 min (around 2.6 folds) and after 30 min (around 7.18 folds) as compared to galangin solution. Such significant increase in galangin amount in the liver for GF68-Gal micelles could be attributed to their efficient targeting to the liver by galactose moieties having affinity towards ASGPR receptor, P-gp and cytochrome enzyme inhibition activity of pluronic F68 reducing the rate of metabolism and in turn elimination. Thus, galactosylated pluronic F68 copolymer can act as a promising carrier system for improving liver targeting of hydrophobic drugs susceptible to P-gp efflux and cytochrome enzyme associated metabolism." @default.
• W2916466206 created "2019-03-02" @default.
• W2916466206 creator A5014328093 @default.
• W2916466206 creator A5030025427 @default.
• W2916466206 creator A5070233576 @default.
• W2916466206 creator A5082064342 @default.
• W2916466206 creator A5088183107 @default.
• W2916466206 date "2019-04-01" @default.
• W2916466206 modified "2023-10-06" @default.
• W2916466206 title "Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting" @default.
• W2916466206 cites W1160632617 @default.
• W2916466206 cites W1965443653 @default.
• W2916466206 cites W1968834637 @default.
• W2916466206 cites W1973514550 @default.
• W2916466206 cites W1993234385 @default.
• W2916466206 cites W2012821120 @default.
• W2916466206 cites W2028853987 @default.
• W2916466206 cites W2037890923 @default.
• W2916466206 cites W2044787665 @default.
• W2916466206 cites W2046785634 @default.
• W2916466206 cites W2047623799 @default.
• W2916466206 cites W2052108548 @default.
• W2916466206 cites W2057782965 @default.
• W2916466206 cites W2064412092 @default.
• W2916466206 cites W2066019546 @default.
• W2916466206 cites W2070801001 @default.
• W2916466206 cites W2071582651 @default.
• W2916466206 cites W2072277020 @default.
• W2916466206 cites W2086654599 @default.
• W2916466206 cites W2093822368 @default.
• W2916466206 cites W2095361794 @default.
• W2916466206 cites W2095795226 @default.
• W2916466206 cites W2098642114 @default.
• W2916466206 cites W2113304554 @default.
• W2916466206 cites W2118071096 @default.
• W2916466206 cites W2130680351 @default.
• W2916466206 cites W2135452103 @default.
• W2916466206 cites W2160168727 @default.
• W2916466206 cites W838936241 @default.
• W2916466206 doi "https://doi.org/10.1016/j.biopha.2019.108691" @default.
• W2916466206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30798131" @default.
• W2916466206 hasPublicationYear "2019" @default.
• W2916466206 type Work @default.
• W2916466206 sameAs 2916466206 @default.
• W2916466206 citedByCount "41" @default.
• W2916466206 countsByYear W29164662062020 @default.
• W2916466206 countsByYear W29164662062021 @default.
• W2916466206 countsByYear W29164662062022 @default.
• W2916466206 countsByYear W29164662062023 @default.
• W2916466206 crossrefType "journal-article" @default.
• W2916466206 hasAuthorship W2916466206A5014328093 @default.
• W2916466206 hasAuthorship W2916466206A5030025427 @default.
• W2916466206 hasAuthorship W2916466206A5070233576 @default.
• W2916466206 hasAuthorship W2916466206A5082064342 @default.
• W2916466206 hasAuthorship W2916466206A5088183107 @default.
• W2916466206 hasBestOaLocation W29164662061 @default.
• W2916466206 hasConcept C101335993 @default.
• W2916466206 hasConcept C11268172 @default.
• W2916466206 hasConcept C12554922 @default.
• W2916466206 hasConcept C150903083 @default.
• W2916466206 hasConcept C15920480 @default.
• W2916466206 hasConcept C178790620 @default.
• W2916466206 hasConcept C184651966 @default.
• W2916466206 hasConcept C185592680 @default.
• W2916466206 hasConcept C202751555 @default.
• W2916466206 hasConcept C207001950 @default.
• W2916466206 hasConcept C2777302768 @default.
• W2916466206 hasConcept C2777807558 @default.
• W2916466206 hasConcept C2777810353 @default.
• W2916466206 hasConcept C2778004101 @default.
• W2916466206 hasConcept C2781263971 @default.
• W2916466206 hasConcept C521977710 @default.
• W2916466206 hasConcept C55493867 @default.
• W2916466206 hasConcept C71924100 @default.
• W2916466206 hasConcept C86803240 @default.
• W2916466206 hasConcept C98274493 @default.
• W2916466206 hasConceptScore W2916466206C101335993 @default.
• W2916466206 hasConceptScore W2916466206C11268172 @default.
• W2916466206 hasConceptScore W2916466206C12554922 @default.
• W2916466206 hasConceptScore W2916466206C150903083 @default.
• W2916466206 hasConceptScore W2916466206C15920480 @default.
• W2916466206 hasConceptScore W2916466206C178790620 @default.
• W2916466206 hasConceptScore W2916466206C184651966 @default.
• W2916466206 hasConceptScore W2916466206C185592680 @default.
• W2916466206 hasConceptScore W2916466206C202751555 @default.
• W2916466206 hasConceptScore W2916466206C207001950 @default.
• W2916466206 hasConceptScore W2916466206C2777302768 @default.
• W2916466206 hasConceptScore W2916466206C2777807558 @default.
• W2916466206 hasConceptScore W2916466206C2777810353 @default.
• W2916466206 hasConceptScore W2916466206C2778004101 @default.
• W2916466206 hasConceptScore W2916466206C2781263971 @default.
• W2916466206 hasConceptScore W2916466206C521977710 @default.
• W2916466206 hasConceptScore W2916466206C55493867 @default.
• W2916466206 hasConceptScore W2916466206C71924100 @default.
• W2916466206 hasConceptScore W2916466206C86803240 @default.
• W2916466206 hasConceptScore W2916466206C98274493 @default.
• W2916466206 hasLocation W29164662061 @default.
• W2916466206 hasLocation W29164662062 @default.

• next