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- W2921869703 abstract "Objective: The cell-cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) is inversely associated with coronary heart disease (CHD) risk. ATP-binding cassette transporter-A1 (ABCA1) plays a crucial role in cholesterol efflux from macrophages to preβ-1-HDL. We tested the hypothesis that CHD patients have functionally abnormal preβ-1-HDL. Approach and Results: We measured HDL CEC via the ABCA1 and the scavenger receptor class B type-I (SR-BI) pathways, HDL anti-oxidative capacity, apolipoprotein A-I-containing HDL particles, and inflammatory- and oxidative-stress markers in 64 CHD cases and 64 gender-matched controls. There were significant positive correlations between ABCA1-dependent cholesterol efflux and the levels of small lipid-poor preβ-1-particles in both cases (R 2 =0.541) and controls (R 2 =0.350). Cases had almost twice the levels of preβ-1-HDL than controls, but the functionality of their preβ-1 particles (preβ-1-concentration-normalized ABCA1-dependent efflux capacity) was significantly lower (-39%). There were significant positive correlations between SR-BI-dependent cholesterol efflux and the levels of large lipid-rich (α-1 + α-2) HDL particles in both cases (R 2 =0.828) and controls (R 2 =0.671). Cases had significantly lower (-11%) levels of large HDL particles, but the functionality of their particles (large-HDL-concentration-normalized SR-BI-dependent efflux capacity) was significantly higher (+27%) compared to controls. High plasma levels of inflammatory and oxidative stress markers were not associated with the functionality of HDL particles. High plasma levels of triglycerides were associated with increased HDL particle functionality. HDL anti-oxidative capacity was significantly lower (-15%) in cases than in controls. There were no significant correlations between HDL anti-oxidative capacity and the concentrations of inflammatory- and oxidative-stress markers or HDL CEC. Conclusions: HDL CEC is significantly influenced by both the concentration and the functionality of specific HDL particles. CHD patients have higher than normal preβ-1 concentration with decreased functionality and lower than normal large-HDL particle concentration with enhanced functionality." @default.
- W2921869703 created "2019-03-22" @default.
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- W2921869703 date "2018-05-01" @default.
- W2921869703 modified "2023-09-27" @default.
- W2921869703 title "Abstract 383: HDL Particles, Cell-Cholesterol Efflux, and CHD Risk: the Preβ-1 Paradox" @default.
- W2921869703 doi "https://doi.org/10.1161/atvb.38.suppl_1.383" @default.
- W2921869703 hasPublicationYear "2018" @default.
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