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• W2923103710 endingPage "1116" @default.
• W2923103710 startingPage "1101" @default.
• W2923103710 abstract "Epigenetic readers are specific proteins which recognize histone marks and represents the underlying mechanism for chromatin regulation. Histone H3 lysine methylation is a potential epigenetic code for the chromatin organization and transcriptional control. Recognition of histone methylation is achieved by evolutionary conserved reader modules known as chromodomain, identified in several proteins, and is involved in transcriptional silencing and chromatin remodelling. Genetic perturbations within the structurally conserved chromodomain could potentially mistarget the reader protein and impair their regulatory pathways, ultimately leading to cellular chaos by setting the stage for tumor development and progression. Here, we report the structural conservations associated with diverse functions, prognostic significance and functional consequences of mutations within chromodomain of human proteins in distinct cancers. We have extensively analysed chromodomain containing human proteins in terms of their structural-functional ability to act as a molecular switch in the recognition of methyl-lysine recognition. We further investigated the combinatorial potential, target promiscuity and binding specificity associated with their underlying mechanisms. Indeed, the molecular mechanism of epigenetic silencing significantly underlies a newer cancer therapy approach. We hope that a critical understanding of chromodomains will pave the way for novel paths of research providing newer insights into the designing of effective anti-cancer therapies." @default.
• W2923103710 created "2019-04-01" @default.
• W2923103710 creator A5006559137 @default.
• W2923103710 creator A5021941753 @default.
• W2923103710 creator A5043926664 @default.
• W2923103710 creator A5055895921 @default.
• W2923103710 creator A5087775910 @default.
• W2923103710 creator A5090187250 @default.
• W2923103710 creator A5090419221 @default.
• W2923103710 date "2019-06-01" @default.
• W2923103710 modified "2023-10-03" @default.
• W2923103710 title "Investigating the structural features of chromodomain proteins in the human genome and predictive impacts of their mutations in cancers" @default.
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