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- W2941403629 abstract "Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019." @default.
- W2941403629 created "2019-05-03" @default.
- W2941403629 creator A5013584043 @default.
- W2941403629 creator A5023108791 @default.
- W2941403629 creator A5031560022 @default.
- W2941403629 creator A5081071864 @default.
- W2941403629 date "2019-04-24" @default.
- W2941403629 modified "2023-10-18" @default.
- W2941403629 title "Biological properties of metal complexes of curcumin" @default.
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