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• W2949891919 abstract "Short tandem repeat (STR) variation has been proposed as a major explanatory factor in the heritability of complex traits in humans and model organisms. However, we still struggle to incorporate STR variation into genotype-phenotype maps. Here, we review the promise of STRs in contributing to complex trait heritability, and highlight the challenges that STRs pose due to their repetitive nature. We argue that STR variants are more likely than single nucleotide variants to have epistatic interactions, reiterate the need for targeted assays to accurately genotype STRs, and call for more appropriate statistical methods in detecting STR-phenotype associations. Lastly, somatic STR variation within individuals may serve as a read-out of disease susceptibility, and is thus potentially a valuable covariate for future association studies." @default.
• W2949891919 created "2019-06-27" @default.
• W2949891919 creator A5014875888 @default.
• W2949891919 creator A5049813467 @default.
• W2949891919 creator A5050779824 @default.
• W2949891919 date "2014-06-18" @default.
• W2949891919 modified "2023-10-16" @default.
• W2949891919 title "The overdue promise of short tandem repeat variation for heritability." @default.
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