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- W2950276841 abstract "Significance Detecting and avoiding noxious stimuli is critical for survival. Nociceptive sensory neurons detect these stimuli and activate neural circuits that elicit stereotyped escape responses. However, individual animals may have genetic predispositions to respond differently to the same stimuli. Furthermore, it is not well understood how experiences during development affect these escape responses. Here, we describe a role for the foraging gene in nociception and show that differences in nociceptive sensitivity may arise from genetic variation of this gene. We also demonstrate that altering synaptic activity in a nociceptive circuit during development changes the sensitivity of the escape response elicited. Our findings suggest that both genetic variation and experiences in development can shape escape responses." @default.
- W2950276841 created "2019-06-27" @default.
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- W2950276841 date "2019-06-18" @default.
- W2950276841 modified "2023-09-25" @default.
- W2950276841 title "<i>Drosophila melanogaster foraging</i> regulates a nociceptive-like escape behavior through a developmentally plastic sensory circuit" @default.
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- W2950276841 doi "https://doi.org/10.1073/pnas.1820840116" @default.
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