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- W2951040280 abstract "Abstract Under physiologically relevant conditions, malondialdehyde reacts smoothly with amine neurotransmitters, i.e. dopamine, norepinephrine and serotonin, to give the fluorescent dihydropyridines 1, 4 and 5, respectively, as the relatively most abundant products. Small amounts of enaminal derivatives, such as 2 and 6, could also be obtained in the reactions with dopamine and serotonin. Oxidation of 1 with hydrogen peroxide/peroxidase leads to a complex pattern of unstable products, the major of which has been isolated and identified as the o-quinone epoxide 7. Similar oxidation of 4 and 5 affords mainly the dihydropyridine 8 and the 4,4′-biindolyl 9, respectively. These results provide new clues to the role of malondialdehyde in neuronal degeneration and lipofuscin formation." @default.
- W2951040280 created "2019-06-27" @default.
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- W2951040280 date "2010-08-13" @default.
- W2951040280 modified "2023-09-25" @default.
- W2951040280 title "ChemInform Abstract: Reaction of Malondialdehyde with Amine Neurotransmitters. Formation and Oxidation Chemistry of Fluorescent 1,4-Dihydropyridine Adducts." @default.
- W2951040280 cites W2014378732 @default.
- W2951040280 doi "https://doi.org/10.1002/chin.199552137" @default.
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