Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954797563> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2954797563 abstract "Abstract Many studies have shown that TP53 mutations play a negative role in antitumor immunity. However, a few studies reported that TP53 mutations could promote antitumor immunity. To explain these contradictory findings, we analyzed five cancer cohorts from The Cancer Genome Atlas (TCGA) project. We found that TP53 -mutated cancers had significantly higher levels of antitumor immune signatures than TP53 -wildtype cancers in breast invasive carcinoma (BRCA) and lung adenocarcinoma (LUAD). In contrast, TP53 -mutated cancers had significantly lower antitumor immune signature levels than TP53 -wildtype cancers in stomach adenocarcinoma (STAD), colon adenocarcinoma (COAD), and head and neck squamous cell carcinoma (HNSC). Moreover, TP53 -mutated cancers likely had higher tumor mutation burden (TMB) and tumor aneuploidy level (TAL) than TP53 -wildtype cancers. However, the TMB differences were more marked between TP53 -mutated and TP53 -wildtype cancers than the TAL differences in BRCA and LUAD, and the TAL differences were more significant in STAD and COAD. Furthermore, we showed that TMB and TAL had a positive and a negative correlation with antitumor immunity and that TMB affected antitumor immunity more greatly than TAL did in BRCA and LUAD while TAL affected antitumor immunity more strongly than TMB in STAD and HNSC. These findings indicate that the distinct correlations between TP53 mutations and antitumor immunity in different cancer types are a consequence of the joint effect of the altered TMB and TAL caused by TP53 mutations on tumor immunity. Our data suggest that the TP53 mutation status could be a useful biomarker for cancer immunotherapy response depending on cancer types." @default.
- W2954797563 created "2019-07-12" @default.
- W2954797563 creator A5004236598 @default.
- W2954797563 creator A5060588206 @default.
- W2954797563 creator A5062755510 @default.
- W2954797563 date "2019-07-04" @default.
- W2954797563 modified "2023-10-17" @default.
- W2954797563 title "Cancer Type-Dependent Correlations betweenTP53Mutations and Antitumor Immunity" @default.
- W2954797563 cites W1817464944 @default.
- W2954797563 cites W2123143632 @default.
- W2954797563 cites W2136859769 @default.
- W2954797563 cites W2159707944 @default.
- W2954797563 cites W2164845904 @default.
- W2954797563 cites W2170490448 @default.
- W2954797563 cites W2317304278 @default.
- W2954797563 cites W2552676993 @default.
- W2954797563 cites W2561459036 @default.
- W2954797563 cites W2574604975 @default.
- W2954797563 cites W2593361213 @default.
- W2954797563 cites W2747774814 @default.
- W2954797563 cites W2752942423 @default.
- W2954797563 cites W2755290882 @default.
- W2954797563 cites W2803592231 @default.
- W2954797563 cites W2803670454 @default.
- W2954797563 cites W2884728705 @default.
- W2954797563 cites W2909679049 @default.
- W2954797563 cites W2952923732 @default.
- W2954797563 doi "https://doi.org/10.1101/692715" @default.
- W2954797563 hasPublicationYear "2019" @default.
- W2954797563 type Work @default.
- W2954797563 sameAs 2954797563 @default.
- W2954797563 citedByCount "0" @default.
- W2954797563 crossrefType "posted-content" @default.
- W2954797563 hasAuthorship W2954797563A5004236598 @default.
- W2954797563 hasAuthorship W2954797563A5060588206 @default.
- W2954797563 hasAuthorship W2954797563A5062755510 @default.
- W2954797563 hasBestOaLocation W29547975631 @default.
- W2954797563 hasConcept C121608353 @default.
- W2954797563 hasConcept C203014093 @default.
- W2954797563 hasConcept C2777701055 @default.
- W2954797563 hasConcept C2779341262 @default.
- W2954797563 hasConcept C2781182431 @default.
- W2954797563 hasConcept C502942594 @default.
- W2954797563 hasConcept C54355233 @default.
- W2954797563 hasConcept C71924100 @default.
- W2954797563 hasConcept C86803240 @default.
- W2954797563 hasConcept C8891405 @default.
- W2954797563 hasConceptScore W2954797563C121608353 @default.
- W2954797563 hasConceptScore W2954797563C203014093 @default.
- W2954797563 hasConceptScore W2954797563C2777701055 @default.
- W2954797563 hasConceptScore W2954797563C2779341262 @default.
- W2954797563 hasConceptScore W2954797563C2781182431 @default.
- W2954797563 hasConceptScore W2954797563C502942594 @default.
- W2954797563 hasConceptScore W2954797563C54355233 @default.
- W2954797563 hasConceptScore W2954797563C71924100 @default.
- W2954797563 hasConceptScore W2954797563C86803240 @default.
- W2954797563 hasConceptScore W2954797563C8891405 @default.
- W2954797563 hasLocation W29547975631 @default.
- W2954797563 hasOpenAccess W2954797563 @default.
- W2954797563 hasPrimaryLocation W29547975631 @default.
- W2954797563 hasRelatedWork W1788730018 @default.
- W2954797563 hasRelatedWork W2055749744 @default.
- W2954797563 hasRelatedWork W2060626309 @default.
- W2954797563 hasRelatedWork W2067692448 @default.
- W2954797563 hasRelatedWork W2331470002 @default.
- W2954797563 hasRelatedWork W2791614387 @default.
- W2954797563 hasRelatedWork W2887205846 @default.
- W2954797563 hasRelatedWork W2892162542 @default.
- W2954797563 hasRelatedWork W2938285217 @default.
- W2954797563 hasRelatedWork W2943002301 @default.
- W2954797563 hasRelatedWork W2998039482 @default.
- W2954797563 hasRelatedWork W3034677806 @default.
- W2954797563 hasRelatedWork W3047317536 @default.
- W2954797563 hasRelatedWork W3099956993 @default.
- W2954797563 hasRelatedWork W3121399681 @default.
- W2954797563 hasRelatedWork W3128814071 @default.
- W2954797563 hasRelatedWork W3159922804 @default.
- W2954797563 hasRelatedWork W3162119075 @default.
- W2954797563 hasRelatedWork W3196946968 @default.
- W2954797563 hasRelatedWork W3211278610 @default.
- W2954797563 isParatext "false" @default.
- W2954797563 isRetracted "false" @default.
- W2954797563 magId "2954797563" @default.
- W2954797563 workType "article" @default.