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• W2955244609 endingPage "e0218738" @default.
• W2955244609 startingPage "e0218738" @default.
• W2955244609 abstract "C. elegans neuronal system constitutes the ideal framework for studying simple, yet realistic, neuronal activity, since the whole nervous system is fully characterized with respect to the exact number of neurons and the neuronal connections. Most recent efforts are devoted to investigate and clarify the signal processing and functional connectivity, which are at the basis of sensing mechanisms, signal transmission, and motor control. In this framework, a refined modelof whole neuron dynamics constitutes a key ingredient to describe the electrophysiological processes, both at thecellular and at the network scale. In this work, we present Hodgkin-Huxley-based models of ion channels dynamics black, built on data available both from C. elegans and from other organisms, expressing homologous channels. We combine these channel models to simulate the electrical activity oftwo among the most studied neurons in C. elegans, which display prototypical dynamics of neuronal activation, the chemosensory AWCON and the motor neuron RMD. Our model properly describes the regenerative responses of the two cells. We analyze in detail the role of ion currents, both in wild type and in in silico knockout neurons. Moreover, we specifically investigate the behavior of RMD, identifying a heterogeneous dynamical response which includes bistable regimes and sustained oscillations. We are able to assess the critical role of T-type calcium currents, carried by CCA-1 channels, and leakage currents in the regulation of RMD response. Overall, our results provide new insights in the activity of key C. elegans neurons. The developed mathematical framework constitute a basis for single-cell and neuronal networks analyses, opening new scenarios in the in silico modeling of C. elegans neuronal system." @default.
• W2955244609 created "2019-07-12" @default.
• W2955244609 creator A5021265523 @default.
• W2955244609 creator A5035182510 @default.
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• W2955244609 creator A5050873342 @default.
• W2955244609 creator A5064461940 @default.
• W2955244609 creator A5083521250 @default.
• W2955244609 date "2019-07-01" @default.
• W2955244609 modified "2023-10-14" @default.
• W2955244609 title "Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD" @default.
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• W2955244609 doi "https://doi.org/10.1371/journal.pone.0218738" @default.
• W2955244609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8389473" @default.
• W2955244609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34437650" @default.
• W2955244609 hasPublicationYear "2019" @default.
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