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- W2967995896 abstract "The chromosomal replication origin region (ori) of characterised bacteria is dynamically positioned throughout the cell cycle. In slowly growing Escherichia coli, ori is maintained at mid-cell from birth until its replication, after which newly replicated sister oris move to opposite quarter positions. Here, we provide an explanation for ori positioning based on the self-organisation of the Structural Maintenance of Chromosomes complex, MukBEF, which forms dynamically positioned clusters on the chromosome. We propose that a non-trivial feedback between the self-organising gradient of MukBEF complexes and the oris leads to accurate ori positioning. We find excellent agreement with quantitative experimental measurements and confirm key predictions. Specifically, we show that oris exhibit biased motion towards MukBEF clusters, rather than mid-cell. Our findings suggest that MukBEF and oris act together as a self-organising system in chromosome organisation-segregation and introduces protein self-organisation as an important consideration for future studies of chromosome dynamics." @default.
- W2967995896 created "2019-08-22" @default.
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- W2967995896 date "2019-08-09" @default.
- W2967995896 modified "2023-10-16" @default.
- W2967995896 title "Self-organised segregation of bacterial chromosomal origins" @default.
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- W2967995896 doi "https://doi.org/10.7554/elife.46564" @default.
- W2967995896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6701925" @default.
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- W2967995896 hasPublicationYear "2019" @default.
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