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- W2968223611 abstract "Aim: To improve the drug delivery to the brain with borneol (Bo)-modified solid lipid nanoparticles (SLNs) of pueraria flavones (PTF) via intranasal administration. Materials & methods: PTF-loaded SLNs were modified with Bo by physical and chemical methods to synthesize PTF-Bo-SA-SLNs and PTF-Bo-SLNs. The prepared SLNs were characterized and their brain delivery effects were evaluated in vitro and in vivo. Results: There was a more pronounced accumulation of PTF-Bo-SA-SLNs in Caco-2 cells. Following intranasal administration, more coumarin-6 was found in the rat brain carried by Bo-SA-SLNs. Brain area under the curve and C max of PTF-Bo-SA-SLN were 7.31- and 7.29-times higher than those of PTF-SLN, respectively. Conclusion: PTF-Bo-SA-SLNs are a promising therapeutic carrier for brain disease after intranasal administration." @default.
- W2968223611 created "2019-08-22" @default.
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- W2968223611 date "2019-08-01" @default.
- W2968223611 modified "2023-10-16" @default.
- W2968223611 title "Improved brain delivery of pueraria flavones via intranasal administration of borneol-modified solid lipid nanoparticles" @default.
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- W2968223611 doi "https://doi.org/10.2217/nnm-2018-0417" @default.
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