Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972616612> ?p ?o ?g. }
- W2972616612 endingPage "2239" @default.
- W2972616612 startingPage "2224" @default.
- W2972616612 abstract "Microvesicles are the body's most powerful intercellular communication system and cancer-initiating cell microvesicles (CIC-TEX) reprogram Non-CIC towards fortified malignancy. Claudin7, a CIC-biomarker in gastrointestinal tumors, is recovered in TEX. Recent evidence suggesting individual cells delivering distinct microvesicles became of particular interest for claudin7, which is part of tight junctions (TJ) and glycolipid-enriched membrane domains (GEM), GEM-located claudin7 is palmitoylated. This offered the unique possibility of exploring the contribution of a CIC marker and its origin from distinct membrane domains on CIC-TEX biogenesis and activities. Proteome and miRNA analysis of wild-type, claudin7-knockdown and a rescue with claudin7 harboring a mutated palmitoylation site (mP) of a rat pancreatic and a human colon cancer line uncovered significant, only partly overlapping contributions of palmitoylated and non-palmitoylated claudin7 to TEX composition. Palmitoylated claudin7 facilitates GEM-integrated plasma membrane and associated signaling molecule recruitment; non-palmitoylated claudin7 supports recruitment of trafficking components, proteins engaged in fatty acid metabolism and TJ proteins into TEX. Claudin7mP also assists TEX recovery of selected miRNA. Thus, distinctly located claudin7 affects CIC-TEX composition and TJ-derived cld7 might play a unique role in equipping CIC-TEX with transporters and lipid metabolism-regulating molecules, awareness of distinct TEX populations being crucial facing therapeutic translation." @default.
- W2972616612 created "2019-09-19" @default.
- W2972616612 creator A5000483058 @default.
- W2972616612 creator A5005561235 @default.
- W2972616612 creator A5008145283 @default.
- W2972616612 creator A5018615422 @default.
- W2972616612 creator A5039406779 @default.
- W2972616612 creator A5078611960 @default.
- W2972616612 creator A5083171620 @default.
- W2972616612 date "2019-01-01" @default.
- W2972616612 modified "2023-10-16" @default.
- W2972616612 title "Distinct Origin of Claudin7 in Early Tumor Endosomes Affects Exosome Assembly" @default.
- W2972616612 cites W1502784604 @default.
- W2972616612 cites W1525870544 @default.
- W2972616612 cites W1530044518 @default.
- W2972616612 cites W1635761634 @default.
- W2972616612 cites W1764838960 @default.
- W2972616612 cites W1885931187 @default.
- W2972616612 cites W1914733225 @default.
- W2972616612 cites W1946170591 @default.
- W2972616612 cites W1956445706 @default.
- W2972616612 cites W1963965802 @default.
- W2972616612 cites W1966048332 @default.
- W2972616612 cites W1978651800 @default.
- W2972616612 cites W1984109999 @default.
- W2972616612 cites W1985175917 @default.
- W2972616612 cites W1999760558 @default.
- W2972616612 cites W2005154332 @default.
- W2972616612 cites W2005755533 @default.
- W2972616612 cites W2009909482 @default.
- W2972616612 cites W2013946487 @default.
- W2972616612 cites W2015696617 @default.
- W2972616612 cites W2015912825 @default.
- W2972616612 cites W2022388990 @default.
- W2972616612 cites W2038236600 @default.
- W2972616612 cites W2038363115 @default.
- W2972616612 cites W2051685028 @default.
- W2972616612 cites W2055313665 @default.
- W2972616612 cites W2056700437 @default.
- W2972616612 cites W2057604945 @default.
- W2972616612 cites W2072167135 @default.
- W2972616612 cites W2081937823 @default.
- W2972616612 cites W2084434670 @default.
- W2972616612 cites W2084648314 @default.
- W2972616612 cites W2097111522 @default.
- W2972616612 cites W2098259366 @default.
- W2972616612 cites W2098583297 @default.
- W2972616612 cites W2109564400 @default.
- W2972616612 cites W2111019629 @default.
- W2972616612 cites W2112519528 @default.
- W2972616612 cites W2112715338 @default.
- W2972616612 cites W2114204804 @default.
- W2972616612 cites W2114775469 @default.
- W2972616612 cites W2134404453 @default.
- W2972616612 cites W2135040607 @default.
- W2972616612 cites W2143729276 @default.
- W2972616612 cites W2143963384 @default.
- W2972616612 cites W2154332155 @default.
- W2972616612 cites W2156694465 @default.
- W2972616612 cites W2168031418 @default.
- W2972616612 cites W2230394794 @default.
- W2972616612 cites W2245165475 @default.
- W2972616612 cites W2270882735 @default.
- W2972616612 cites W2282270705 @default.
- W2972616612 cites W2312987066 @default.
- W2972616612 cites W2325305253 @default.
- W2972616612 cites W2337609917 @default.
- W2972616612 cites W2340514456 @default.
- W2972616612 cites W2398516887 @default.
- W2972616612 cites W2406723770 @default.
- W2972616612 cites W2410659882 @default.
- W2972616612 cites W2415734547 @default.
- W2972616612 cites W2416973816 @default.
- W2972616612 cites W2475095497 @default.
- W2972616612 cites W2508743435 @default.
- W2972616612 cites W2511069824 @default.
- W2972616612 cites W2594599876 @default.
- W2972616612 cites W2604274693 @default.
- W2972616612 cites W2707015926 @default.
- W2972616612 cites W2766284882 @default.
- W2972616612 cites W2795537003 @default.
- W2972616612 cites W2802758935 @default.
- W2972616612 cites W2803738393 @default.
- W2972616612 cites W2803837186 @default.
- W2972616612 cites W291804278 @default.
- W2972616612 cites W2923361621 @default.
- W2972616612 cites W2925418003 @default.
- W2972616612 cites W301388723 @default.
- W2972616612 cites W4243653664 @default.
- W2972616612 doi "https://doi.org/10.7150/ijbs.35347" @default.
- W2972616612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6775303" @default.
- W2972616612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31592143" @default.
- W2972616612 hasPublicationYear "2019" @default.
- W2972616612 type Work @default.
- W2972616612 sameAs 2972616612 @default.
- W2972616612 citedByCount "5" @default.
- W2972616612 countsByYear W29726166122019 @default.
- W2972616612 countsByYear W29726166122020 @default.