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- W2972871198 endingPage "104611" @default.
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- W2972871198 abstract "Traumatic brain injury (TBI) is a leading cause of long-term disability in the United States. Even in comparatively mild injuries, cognitive and behavioral symptoms can persist for years, and there are currently no established strategies for mitigating symptoms in chronic injury. A key feature of TBI-induced damage in acute and chronic injury is disruption of metabolic pathways. As neurotransmission, and therefore cognition, are highly dependent on the supply of energy, we hypothesized that modulating metabolic activity could help restore behavioral performance even when treatment was initiated weeks after TBI. We treated rats with pioglitazone, a FDA-approved drug for diabetes, beginning 46 days after lateral fluid percussion injury and tested working memory performance in the radial arm maze (RAM) after 14 days of treatment. Pioglitazone treated TBI rats performed significantly better in the RAM test than untreated TBI rats, and similarly to control animals. While hexokinase activity in hippocampus was increased by pioglitazone treatment, there was no upregulation of either the neuronal glucose transporter or hexokinase enzyme expression. Expression of glial markers GFAP and Iba-1 were also not influenced by pioglitazone treatment. These studies suggest that targeting brain metabolism, in particular hippocampal metabolism, may be effective in alleviating cognitive symptoms in chronic TBI." @default.
- W2972871198 created "2019-09-19" @default.
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- W2972871198 date "2019-12-01" @default.
- W2972871198 modified "2023-09-23" @default.
- W2972871198 title "Pioglitazone improves working memory performance when administered in chronic TBI" @default.
- W2972871198 cites W1535379795 @default.
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- W2972871198 cites W1965395380 @default.
- W2972871198 cites W1966244691 @default.
- W2972871198 cites W1966401421 @default.
- W2972871198 cites W1968639827 @default.
- W2972871198 cites W1969826866 @default.
- W2972871198 cites W1974434672 @default.
- W2972871198 cites W1976072714 @default.
- W2972871198 cites W1976527985 @default.
- W2972871198 cites W1991210201 @default.
- W2972871198 cites W1994256646 @default.
- W2972871198 cites W1999856629 @default.
- W2972871198 cites W2000010591 @default.
- W2972871198 cites W2000901251 @default.
- W2972871198 cites W2001068966 @default.
- W2972871198 cites W2004945782 @default.
- W2972871198 cites W2005536744 @default.
- W2972871198 cites W2009447734 @default.
- W2972871198 cites W2013332914 @default.
- W2972871198 cites W2021350175 @default.
- W2972871198 cites W2031773477 @default.
- W2972871198 cites W2037519324 @default.
- W2972871198 cites W2044057452 @default.
- W2972871198 cites W2048308976 @default.
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- W2972871198 cites W2057696398 @default.
- W2972871198 cites W2060337173 @default.
- W2972871198 cites W2064836594 @default.
- W2972871198 cites W2069183695 @default.
- W2972871198 cites W2069633211 @default.
- W2972871198 cites W2070221838 @default.
- W2972871198 cites W2078526156 @default.
- W2972871198 cites W2079233663 @default.
- W2972871198 cites W2080814525 @default.
- W2972871198 cites W2083202625 @default.
- W2972871198 cites W2084566588 @default.
- W2972871198 cites W2084969905 @default.
- W2972871198 cites W2087175538 @default.
- W2972871198 cites W2087480088 @default.
- W2972871198 cites W2088335733 @default.
- W2972871198 cites W2092814867 @default.
- W2972871198 cites W2108149698 @default.
- W2972871198 cites W2127552748 @default.
- W2972871198 cites W2128011380 @default.
- W2972871198 cites W2131651771 @default.
- W2972871198 cites W2137070227 @default.
- W2972871198 cites W2146569853 @default.
- W2972871198 cites W2149506749 @default.
- W2972871198 cites W2151288054 @default.
- W2972871198 cites W2297591945 @default.
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- W2972871198 cites W2558343000 @default.
- W2972871198 cites W2567971507 @default.
- W2972871198 cites W2583897314 @default.
- W2972871198 cites W2598642148 @default.
- W2972871198 cites W2609465808 @default.
- W2972871198 cites W2756198855 @default.
- W2972871198 cites W2793220343 @default.
- W2972871198 cites W2805943226 @default.
- W2972871198 cites W2806143103 @default.
- W2972871198 cites W2887397955 @default.
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- W2972871198 cites W2931141042 @default.
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- W2972871198 doi "https://doi.org/10.1016/j.nbd.2019.104611" @default.
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- W2972871198 hasPublicationYear "2019" @default.
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