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• W2975742247 abstract "ObjectiveWe sought to identify whether chronic opioid users are at increased risk for complications or hospital readmission following lobectomy for non–small cell lung cancer.MethodsThe National Cancer Institute Surveillance, Epidemiology, and End Results-Medicare database was queried to identify patients older than age 65 years who received a lobectomy for non–small cell lung cancer. Chronic opioid users were identified through Medicare Part D records and were defined as those with >120 cumulative days of opioid supply for the year before surgery. A systematic 1:2 propensity matching was performed among chronic opioid users.ResultsSix thousand four hundred thirty-seven patients were identified, among whom 3627 (56%) were opioid naïve, 1866 (29%) were intermittent opioid users, and 944 (15%) were chronic opioid users. After propensity matching, 30-day mortality and 90-day mortality were nearly 2-fold higher among chronic opioid users compared with nonchronic users. In addition, length of stay and hospital charges were increased among chronic opioid users (median, 6 vs 7 days and mean increase, $12,526, respectively). Multivariable analysis revealed that intermittent opioid users and chronic opioid users were associated with an increased risk of 90-day hospital readmission compared with opioid-naïve patients (odds ratio, 1.35; 95% confidence interval, 1.07-1.71 and odds ratio, 1.72; 95% confidence interval, 1.40-2.12, respectively), predominantly burdened by infectious, renal, and pulmonary causes.ConclusionsPatients who chronically use opioids before lobectomy represent high-risk patients. The risk of 30- and 90-day mortality, length of stay, hospital charges, and 90-day readmission after lobectomy among chronic opioid users are substantially elevated." @default.
• W2975742247 created "2019-10-03" @default.
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• W2975742247 date "2020-02-01" @default.
• W2975742247 modified "2023-10-03" @default.
• W2975742247 title "Perioperative outcomes among chronic opioid users who receive lobectomy for non–small cell lung cancer" @default.
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• W2975742247 doi "https://doi.org/10.1016/j.jtcvs.2019.09.059" @default.
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