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- W2989601064 abstract "Autoimmunity and chronic viral infections are recurrent clinical observations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a complex disease with an unknown cause. Given these observations, the regulatory CD4+ T cells (Tregs) show promise to be good candidates for the underlying pathology due to their capacity to suppress the immune responses against both self and microbial antigens. Here, we discussed the overlooked role of these cells in the chronicity of Human Herpes Virus 6 (HHV6), Herpes Simplex 1 (HSV1), and Epstein-Barr virus (EBV), as often reported as triggers of ME/CFS. Using simulations of the cross-regulation model for the dynamics of Tregs, we illustrated that mild infections might lead to a chronically activated immune responses under control of Tregs if the responding clone has a high autoimmune potential. Such infections promote persistent inflammation and possibly fatigue. We then hypothesized that ME/CFS is a condition characterized by a predominance of this type of infections under control of Tregs. In contrast, healthy individuals are hypothesized to trigger immune responses of a virus-specific clone with a low autoimmune potential. According to this hypothesis, simple model simulations of the CD4+ T-cell repertoire could reproduce the increased density and percentages of Tregs observed in patients suffering from the disease, when compared to healthy controls. A deeper analysis of Tregs in the pathogenesis of ME/CFS will help to assess the validity of this hypothesis." @default.
- W2989601064 created "2019-12-05" @default.
- W2989601064 creator A5060343179 @default.
- W2989601064 creator A5076692042 @default.
- W2989601064 creator A5077907498 @default.
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- W2989601064 date "2019-11-21" @default.
- W2989601064 modified "2023-10-14" @default.
- W2989601064 title "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections" @default.
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- W2989601064 doi "https://doi.org/10.3389/fimmu.2019.02684" @default.
- W2989601064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6883905" @default.
- W2989601064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31824487" @default.
- W2989601064 hasPublicationYear "2019" @default.
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