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- W2989622338 abstract "Abstract Direct renin inhibitors (DRIs) block the activation of the alternative complement pathway in vitro and could be a treatment option for refractory hypertension in atypical hemolytic uremic syndrome (aHUS). A 20-year-old male presented with primary aHUS complicated by end-stage renal disease and refractory malignant hypertension despite being on five antihypertensive medications at maximum dose. Only a partial response was achieved with aliskiren and eculizumab, but after increasing aliskiren to a supratherapeutic dose, antihypertensive medication was reduced, platelets increased, C3 increased and epoetin alfa requirement decreased. DRI may be an adjunct treatment for malignant hypertension associated with aHUS." @default.
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- W2989622338 date "2019-11-22" @default.
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- W2989622338 title "Aliskiren as an adjunct therapy for atypical hemolytic uremic syndrome" @default.
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- W2989622338 doi "https://doi.org/10.1093/ckj/sfz146" @default.
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