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- W2990132414 abstract "Objective: The present study aims to synthesize and biological evaluation of benzimidazole derivatives as antimicrobial agents.
 Methods: 2-Methylbenzimidazole react with ethyl-chloroacetate gives N1-Ethylacetate-2-methyl-benzimidazole (1), which on reaction with thiosemicarbazide gives N1-acetylthiosemicarbazide-2-methyl-benzimidazole (2). The compound (2) on dehydrative annulation by mineral acid gives N1-(2’-amino-5’-methylene)-1’,3’,4’-thiadiazole-2-methyl-benzimidazole(3), which on condensation with various aromatic and hetero aromatic aldehydes gives N1-(2-substituted-Benzylidene-imino-5’-methylene)-1’, 3’, 4’-Thiadiazole]-2-methyl-benzimidazole(4a-4l).
 Results: The reaction sequence involves microwave-induced preparation of N1-Ethylacetate-2-methyl-benzimidazole (1) from reaction of 2-methylbenzimidazole with ethyl-chloroacetate. Further reaction with thiosemicarbazide gives N1-acetylthiosemicarbazide-2-methyl-benzimidazole (2). The compound (2) on dehydrative annulation by sulfuric acid gives N1-(2’-amino-5’-methylene)-1’,3’,4’-thiadiazole-2-methyl-benzimidazole(3), which on condensation with various aromatic and hetero aromatic aldehydes gives N1-(2-substituted-Benzylidene-imino-5’-methylene)-1’, 3’, 4’-Thiadiazole]-2-methyl-benzimidazole(4a-4l). Which were characterized by IR and 1H NMR spectral data.
 Conclusion: All the synthesized compounds were screened for antimicrobial activity by cup plate method. Most of the derivatives showed good antimicrobial activity against Gram-Positive and Gram-negative bacteria." @default.
- W2990132414 created "2019-12-05" @default.
- W2990132414 creator A5033023357 @default.
- W2990132414 creator A5053365852 @default.
- W2990132414 date "2019-11-13" @default.
- W2990132414 modified "2023-09-23" @default.
- W2990132414 title "SYNTHESIS AND BIOLOGICAL EVALUATION OF BENZIMIDAZOLE DERIVATIVES AS ANTIMICROBIAL AGENTS" @default.
- W2990132414 doi "https://doi.org/10.22159/ijcpr.2019v11i6.36356" @default.
- W2990132414 hasPublicationYear "2019" @default.
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