Matches in SemOpenAlex for { <https://semopenalex.org/work/W2992952823> ?p ?o ?g. }
- W2992952823 abstract "Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10−6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake." @default.
- W2992952823 created "2019-12-13" @default.
- W2992952823 creator A5000822794 @default.
- W2992952823 creator A5002276836 @default.
- W2992952823 creator A5003560505 @default.
- W2992952823 creator A5003790056 @default.
- W2992952823 creator A5004063604 @default.
- W2992952823 creator A5004538115 @default.
- W2992952823 creator A5004801902 @default.
- W2992952823 creator A5004832167 @default.
- W2992952823 creator A5005038797 @default.
- W2992952823 creator A5006204469 @default.
- W2992952823 creator A5006311386 @default.
- W2992952823 creator A5006794336 @default.
- W2992952823 creator A5006966796 @default.
- W2992952823 creator A5007870782 @default.
- W2992952823 creator A5008751750 @default.
- W2992952823 creator A5008874281 @default.
- W2992952823 creator A5009270847 @default.
- W2992952823 creator A5011269649 @default.
- W2992952823 creator A5012777958 @default.
- W2992952823 creator A5013920089 @default.
- W2992952823 creator A5014761203 @default.
- W2992952823 creator A5015751984 @default.
- W2992952823 creator A5017572190 @default.
- W2992952823 creator A5018093575 @default.
- W2992952823 creator A5020035575 @default.
- W2992952823 creator A5020170160 @default.
- W2992952823 creator A5020304503 @default.
- W2992952823 creator A5022907613 @default.
- W2992952823 creator A5022974046 @default.
- W2992952823 creator A5027220505 @default.
- W2992952823 creator A5027349128 @default.
- W2992952823 creator A5027538163 @default.
- W2992952823 creator A5029044079 @default.
- W2992952823 creator A5029677986 @default.
- W2992952823 creator A5031200792 @default.
- W2992952823 creator A5031306803 @default.
- W2992952823 creator A5031530236 @default.
- W2992952823 creator A5032143962 @default.
- W2992952823 creator A5032537180 @default.
- W2992952823 creator A5033441851 @default.
- W2992952823 creator A5035293496 @default.
- W2992952823 creator A5035488928 @default.
- W2992952823 creator A5037535897 @default.
- W2992952823 creator A5039032883 @default.
- W2992952823 creator A5039611937 @default.
- W2992952823 creator A5040604700 @default.
- W2992952823 creator A5040770914 @default.
- W2992952823 creator A5041676520 @default.
- W2992952823 creator A5041918436 @default.
- W2992952823 creator A5042114539 @default.
- W2992952823 creator A5042121948 @default.
- W2992952823 creator A5043373639 @default.
- W2992952823 creator A5043442650 @default.
- W2992952823 creator A5043791314 @default.
- W2992952823 creator A5044144962 @default.
- W2992952823 creator A5044277116 @default.
- W2992952823 creator A5045399741 @default.
- W2992952823 creator A5047478353 @default.
- W2992952823 creator A5048196698 @default.
- W2992952823 creator A5048525391 @default.
- W2992952823 creator A5051610805 @default.
- W2992952823 creator A5053091216 @default.
- W2992952823 creator A5054782619 @default.
- W2992952823 creator A5055313700 @default.
- W2992952823 creator A5055584673 @default.
- W2992952823 creator A5056272495 @default.
- W2992952823 creator A5056326170 @default.
- W2992952823 creator A5056685687 @default.
- W2992952823 creator A5059072765 @default.
- W2992952823 creator A5059560495 @default.
- W2992952823 creator A5059670464 @default.
- W2992952823 creator A5060131080 @default.
- W2992952823 creator A5060136612 @default.
- W2992952823 creator A5060175597 @default.
- W2992952823 creator A5061974826 @default.
- W2992952823 creator A5062296084 @default.
- W2992952823 creator A5063552729 @default.
- W2992952823 creator A5064118768 @default.
- W2992952823 creator A5064837983 @default.
- W2992952823 creator A5066237154 @default.
- W2992952823 creator A5066734451 @default.
- W2992952823 creator A5067387552 @default.
- W2992952823 creator A5068641801 @default.
- W2992952823 creator A5069416517 @default.
- W2992952823 creator A5069528720 @default.
- W2992952823 creator A5070156525 @default.
- W2992952823 creator A5072970006 @default.
- W2992952823 creator A5073029734 @default.
- W2992952823 creator A5076740728 @default.
- W2992952823 creator A5077037910 @default.
- W2992952823 creator A5079122854 @default.
- W2992952823 creator A5079276216 @default.
- W2992952823 creator A5079359230 @default.
- W2992952823 creator A5080760027 @default.
- W2992952823 creator A5081119135 @default.
- W2992952823 creator A5081478760 @default.
- W2992952823 creator A5081986241 @default.
- W2992952823 creator A5082712082 @default.