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• W3000731951 endingPage "118" @default.
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• W3000731951 abstract "Abstract The primary cause of harmaline tremor, which is a model of essential tremor (ET) in animals, is excessive activation of olivocerebellar glutamatergic climbing fibers. Our recent study indicated that 5′-chloro-5′-deoxy-(±)-N6-(±)-(endo-norborn-2-yl)adenosine (5′Cl5′d-(±)-ENBA), a potent and selective adenosine A1 receptor (A1) agonist, inhibited harmaline tremor. The present study was aimed to evaluate the role of glutamatergic transmission system in 5′Cl5′d-(±)-ENBA tremorolytic action in the harmaline model in rats, by analyzing glutamate release in the motor nuclei of the thalamus and mRNA expression of glutamatergic neuron markers (vGlut1/2) in reference to the general neuronal activity marker (zif-268) in different brain structures. The extracellular glutamate level in the motor thalamus was evaluated by in vivo microdialysis and the vGlut1/vGlut2 and zif-268 mRNA expression was analyzed by in situ hybridization. The intensity of tremor was measured automatically using Force Plate Actimeters (FPAs). 5′Cl5′d-(±)-ENBA (0.5 mg/kg) given 30 min before harmaline (30 mg/kg) decreased the harmaline-induced excessive glutamate release in the motor thalamus and reversed harmaline - induced molecular effects, such as elevation of the vGlut1 mRNA expression in the inferior olive (IO) and decrease in the motor cortex, as well as an increase of the zif-268 mRNA expression in the IO, motor thalamus and motor cortex. Moreover, 5′Cl5′d-(±)-ENBA reduced harmaline tremor by lowering its power in 9–15 Hz frequency band. Our findings show that A1 stimulation decreases glutamate release in the motor thalamic nuclei in the harmaline model of ET, suggesting that A1 receptors, especially in this structure, may be a potential therapeutic target in this disorder." @default.
• W3000731951 created "2020-01-23" @default.
• W3000731951 creator A5022576027 @default.
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• W3000731951 date "2020-03-01" @default.
• W3000731951 modified "2023-09-27" @default.
• W3000731951 title "Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5′-Chloro-5′-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor" @default.
• W3000731951 cites W1960153579 @default.
• W3000731951 cites W1964745945 @default.
• W3000731951 cites W1964912132 @default.
• W3000731951 cites W1968716671 @default.
• W3000731951 cites W1970175928 @default.
• W3000731951 cites W1971711531 @default.
• W3000731951 cites W1971837740 @default.
• W3000731951 cites W1979634104 @default.
• W3000731951 cites W1988189610 @default.
• W3000731951 cites W1988480319 @default.
• W3000731951 cites W1988613431 @default.
• W3000731951 cites W1990615527 @default.
• W3000731951 cites W1992613763 @default.
• W3000731951 cites W1994413077 @default.
• W3000731951 cites W1997047222 @default.
• W3000731951 cites W1999252843 @default.
• W3000731951 cites W2001431383 @default.
• W3000731951 cites W2007589759 @default.
• W3000731951 cites W2016036161 @default.
• W3000731951 cites W2018576843 @default.
• W3000731951 cites W2018654901 @default.
• W3000731951 cites W2021527106 @default.
• W3000731951 cites W2024448485 @default.
• W3000731951 cites W2027340604 @default.
• W3000731951 cites W2028474222 @default.
• W3000731951 cites W2033011398 @default.
• W3000731951 cites W2036282801 @default.
• W3000731951 cites W2043113634 @default.
• W3000731951 cites W2045785508 @default.
• W3000731951 cites W2046371100 @default.
• W3000731951 cites W2050123488 @default.
• W3000731951 cites W2051874000 @default.
• W3000731951 cites W2053269045 @default.
• W3000731951 cites W2053593015 @default.
• W3000731951 cites W2054355200 @default.
• W3000731951 cites W2056035374 @default.
• W3000731951 cites W2057355158 @default.
• W3000731951 cites W2057956003 @default.
• W3000731951 cites W2061494834 @default.
• W3000731951 cites W2063880987 @default.
• W3000731951 cites W2067225716 @default.
• W3000731951 cites W2068743427 @default.
• W3000731951 cites W2071148558 @default.
• W3000731951 cites W2071833250 @default.
• W3000731951 cites W2085580182 @default.
• W3000731951 cites W2100544352 @default.
• W3000731951 cites W2102248966 @default.
• W3000731951 cites W2110742628 @default.
• W3000731951 cites W2113670054 @default.
• W3000731951 cites W2114971316 @default.
• W3000731951 cites W2120168553 @default.
• W3000731951 cites W2124565900 @default.
• W3000731951 cites W2133041352 @default.
• W3000731951 cites W2133177004 @default.
• W3000731951 cites W2138425268 @default.
• W3000731951 cites W2150014159 @default.
• W3000731951 cites W2163934970 @default.
• W3000731951 cites W2171136974 @default.
• W3000731951 cites W2171685713 @default.
• W3000731951 cites W2171884247 @default.
• W3000731951 cites W2177890476 @default.
• W3000731951 cites W2213314638 @default.
• W3000731951 cites W2225695071 @default.
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• W3000731951 cites W2774902757 @default.
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• W3000731951 doi "https://doi.org/10.1016/j.neuroscience.2019.12.045" @default.
• W3000731951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31935489" @default.
• W3000731951 hasPublicationYear "2020" @default.
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