Matches in SemOpenAlex for { <https://semopenalex.org/work/W300384401> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W300384401 abstract "Vascular stents often cause adverse physiological responses as a result of inadequate endothelialcoverage. The new generation of vascular stent designs includes substratums with nanopatternedtopographies that enhance cell functionality for rapid endothelialization. Quick endothelializationcan be achieved by promoting cell migration rate and guiding cell migration direction, factorsaccomplishable by durotaxis, stiffness directed cell motility. However, the stiffness gradientrequired to induce durotaxis has not yet been implemented in materials viable for vascular stents.Our objective is to improve upon existing stent designs through durotaxis by studyingendothelial cell migration on biodegradable chitosan modified with nanopatternedtopography and gradated stiffness. We will fabricate three nanostructured substrates with 400nm pitch rectangular grooves and ridges possessing different stiffness gradients of 1 Pa/um, 10Pa/um, and 100 Pa/um and seed them with human umbilical vein and human aortic endothelialcells. We expect our nanostructured substrates will outperform our only topographicallymodified (no stiffness gradient) control and flat surface control. The proposed study will not onlyoffer a potential solution for improved endothelialization but also offer a proof of concept forintegration of durotaxis to vascular stent designs.." @default.
- W300384401 created "2016-06-24" @default.
- W300384401 creator A5072402213 @default.
- W300384401 date "2014-01-01" @default.
- W300384401 modified "2023-09-24" @default.
- W300384401 title "Durotaxis Directed Cell Migration for Enhanced Vascular Stent Endothelialization" @default.
- W300384401 cites W1527614413 @default.
- W300384401 cites W1970516435 @default.
- W300384401 cites W1973089587 @default.
- W300384401 cites W1979219809 @default.
- W300384401 cites W1979583116 @default.
- W300384401 cites W1987484662 @default.
- W300384401 cites W1990383316 @default.
- W300384401 cites W1991814943 @default.
- W300384401 cites W1993222177 @default.
- W300384401 cites W1993698162 @default.
- W300384401 cites W1995660244 @default.
- W300384401 cites W2002107142 @default.
- W300384401 cites W2010513961 @default.
- W300384401 cites W2010846389 @default.
- W300384401 cites W2011481699 @default.
- W300384401 cites W2022050717 @default.
- W300384401 cites W2023995606 @default.
- W300384401 cites W2024250498 @default.
- W300384401 cites W2033858953 @default.
- W300384401 cites W2055919941 @default.
- W300384401 cites W2059838774 @default.
- W300384401 cites W2070663004 @default.
- W300384401 cites W2078035463 @default.
- W300384401 cites W2081910439 @default.
- W300384401 cites W2085296378 @default.
- W300384401 cites W2086989629 @default.
- W300384401 cites W2094965469 @default.
- W300384401 cites W2098947128 @default.
- W300384401 cites W2114467659 @default.
- W300384401 cites W2124488388 @default.
- W300384401 cites W2145524503 @default.
- W300384401 cites W2153037869 @default.
- W300384401 cites W2159032983 @default.
- W300384401 cites W2162028384 @default.
- W300384401 cites W2163512781 @default.
- W300384401 cites W38669844 @default.
- W300384401 cites W44022962 @default.
- W300384401 doi "https://doi.org/10.5070/m471025005" @default.
- W300384401 hasPublicationYear "2014" @default.
- W300384401 type Work @default.
- W300384401 sameAs 300384401 @default.
- W300384401 citedByCount "0" @default.
- W300384401 crossrefType "journal-article" @default.
- W300384401 hasAuthorship W300384401A5072402213 @default.
- W300384401 hasBestOaLocation W3003844011 @default.
- W300384401 hasConcept C136229726 @default.
- W300384401 hasConcept C137738243 @default.
- W300384401 hasConcept C141071460 @default.
- W300384401 hasConcept C1491633281 @default.
- W300384401 hasConcept C159985019 @default.
- W300384401 hasConcept C185592680 @default.
- W300384401 hasConcept C192562407 @default.
- W300384401 hasConcept C202751555 @default.
- W300384401 hasConcept C2777411675 @default.
- W300384401 hasConcept C2778583881 @default.
- W300384401 hasConcept C2779372316 @default.
- W300384401 hasConcept C55493867 @default.
- W300384401 hasConcept C71924100 @default.
- W300384401 hasConceptScore W300384401C136229726 @default.
- W300384401 hasConceptScore W300384401C137738243 @default.
- W300384401 hasConceptScore W300384401C141071460 @default.
- W300384401 hasConceptScore W300384401C1491633281 @default.
- W300384401 hasConceptScore W300384401C159985019 @default.
- W300384401 hasConceptScore W300384401C185592680 @default.
- W300384401 hasConceptScore W300384401C192562407 @default.
- W300384401 hasConceptScore W300384401C202751555 @default.
- W300384401 hasConceptScore W300384401C2777411675 @default.
- W300384401 hasConceptScore W300384401C2778583881 @default.
- W300384401 hasConceptScore W300384401C2779372316 @default.
- W300384401 hasConceptScore W300384401C55493867 @default.
- W300384401 hasConceptScore W300384401C71924100 @default.
- W300384401 hasLocation W3003844011 @default.
- W300384401 hasOpenAccess W300384401 @default.
- W300384401 hasPrimaryLocation W3003844011 @default.
- W300384401 hasRelatedWork W13848843 @default.
- W300384401 hasRelatedWork W1995402002 @default.
- W300384401 hasRelatedWork W2030982076 @default.
- W300384401 hasRelatedWork W2066574979 @default.
- W300384401 hasRelatedWork W2159032983 @default.
- W300384401 hasRelatedWork W2324751974 @default.
- W300384401 hasRelatedWork W2471211166 @default.
- W300384401 hasRelatedWork W2984278889 @default.
- W300384401 isParatext "false" @default.
- W300384401 isRetracted "false" @default.
- W300384401 magId "300384401" @default.
- W300384401 workType "article" @default.