Matches in SemOpenAlex for { <https://semopenalex.org/work/W3004865147> ?p ?o ?g. }
- W3004865147 abstract "The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when the epiblast generates mesoderm and endoderm germ layers through epithelial-mesenchymal transition (EMT). Although gastrulation EMT coincides with loss of epiblast pluripotency, pluripotent cells in development and in vitro can adopt either mesenchymal or epithelial morphology. The relationship between epiblast cellular morphology and its pluripotency is not well understood. Here, using chicken epiblast and mammalian pluripotency stem cell (PSC) models, we show that PSCs undergo a mesenchymal-epithelial transition (MET) prior to EMT-associated pluripotency loss. Epiblast MET and its subsequent EMT are two distinct processes. The former, a partial MET, is associated with reversible initiation of pluripotency exit, whereas the latter, a full EMT, is associated with complete and irreversible pluripotency loss. We provide evidence that integrin-mediated cell-matrix interaction is a key player in pluripotency exit regulation. We propose that epiblast partial MET is an evolutionarily conserved process among all amniotic vertebrates and that epiblast pluripotency is restricted to an intermediate cellular state residing between the fully mesenchymal and fully epithelial states." @default.
- W3004865147 created "2020-02-14" @default.
- W3004865147 creator A5011582383 @default.
- W3004865147 creator A5019319065 @default.
- W3004865147 creator A5022896439 @default.
- W3004865147 creator A5029439512 @default.
- W3004865147 creator A5045031806 @default.
- W3004865147 creator A5064949815 @default.
- W3004865147 creator A5066531799 @default.
- W3004865147 creator A5069600769 @default.
- W3004865147 creator A5074959122 @default.
- W3004865147 creator A5079161605 @default.
- W3004865147 creator A5086527421 @default.
- W3004865147 date "2020-02-01" @default.
- W3004865147 modified "2023-10-03" @default.
- W3004865147 title "Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation" @default.
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