Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016283877> ?p ?o ?g. }
- W3016283877 abstract "Abstract Gene regulatory changes underlie much of phenotypic evolution. However, the evolutionary potential of regulatory evolution is unknown, because most evidence comes from either natural variation or limited experimental perturbations. Surveying an unbiased mutation library for a developmental enhancer in Drosophila melanogaster using an automated robotics pipeline, we found that most mutations alter gene expression. Our results suggest that regulatory information is distributed throughout most of a developmental enhancer and that parameters of gene expression—levels, location, and state—are convolved. The widespread pleiotropic effects of most mutations and the codependency of outputs may constrain the evolvability of developmental enhancers. Consistent with these observations, comparisons of diverse drosophilids reveal mainly stasis and apparent biases in the phenotypes influenced by this enhancer. Developmental enhancers may encode a much higher density of regulatory information than has been appreciated previously, which may impose constraints on regulatory evolution. Quote “Rock, robot rock Rock, robot rock Rock, robot rock” Daft Punk (2005)" @default.
- W3016283877 created "2020-04-24" @default.
- W3016283877 creator A5000275701 @default.
- W3016283877 creator A5007394641 @default.
- W3016283877 creator A5013597002 @default.
- W3016283877 creator A5021505844 @default.
- W3016283877 creator A5022956981 @default.
- W3016283877 creator A5028046698 @default.
- W3016283877 creator A5050218156 @default.
- W3016283877 creator A5072133775 @default.
- W3016283877 creator A5073493153 @default.
- W3016283877 creator A5078242769 @default.
- W3016283877 creator A5085233233 @default.
- W3016283877 date "2020-04-18" @default.
- W3016283877 modified "2023-09-26" @default.
- W3016283877 title "Dense encoding of developmental regulatory information may constrain evolvability" @default.
- W3016283877 cites W1968189089 @default.
- W3016283877 cites W1968203653 @default.
- W3016283877 cites W1972013835 @default.
- W3016283877 cites W1985237887 @default.
- W3016283877 cites W1989004527 @default.
- W3016283877 cites W2000572318 @default.
- W3016283877 cites W2002964220 @default.
- W3016283877 cites W2006328220 @default.
- W3016283877 cites W2006824094 @default.
- W3016283877 cites W2012203291 @default.
- W3016283877 cites W2021373833 @default.
- W3016283877 cites W2023738280 @default.
- W3016283877 cites W2027946350 @default.
- W3016283877 cites W2040805319 @default.
- W3016283877 cites W2042094955 @default.
- W3016283877 cites W2045362835 @default.
- W3016283877 cites W2046289407 @default.
- W3016283877 cites W2046727187 @default.
- W3016283877 cites W2049905446 @default.
- W3016283877 cites W2056707311 @default.
- W3016283877 cites W2061484820 @default.
- W3016283877 cites W2069769149 @default.
- W3016283877 cites W2089806726 @default.
- W3016283877 cites W2100990361 @default.
- W3016283877 cites W2112500061 @default.
- W3016283877 cites W2113158813 @default.
- W3016283877 cites W2114850508 @default.
- W3016283877 cites W2117549173 @default.
- W3016283877 cites W2128016314 @default.
- W3016283877 cites W2131534552 @default.
- W3016283877 cites W2132224717 @default.
- W3016283877 cites W2140538490 @default.
- W3016283877 cites W2141354959 @default.
- W3016283877 cites W2152910720 @default.
- W3016283877 cites W2155585326 @default.
- W3016283877 cites W2155940790 @default.
- W3016283877 cites W2167279371 @default.
- W3016283877 cites W2167852161 @default.
- W3016283877 cites W2285281835 @default.
- W3016283877 cites W2308616703 @default.
- W3016283877 cites W2342249984 @default.
- W3016283877 cites W2345943684 @default.
- W3016283877 cites W2409455737 @default.
- W3016283877 cites W2462656404 @default.
- W3016283877 cites W2536097271 @default.
- W3016283877 cites W2536392178 @default.
- W3016283877 cites W2556513628 @default.
- W3016283877 cites W2570668323 @default.
- W3016283877 cites W2592918382 @default.
- W3016283877 cites W2755853637 @default.
- W3016283877 cites W2758109932 @default.
- W3016283877 cites W2790089517 @default.
- W3016283877 cites W2884105770 @default.
- W3016283877 cites W2902937254 @default.
- W3016283877 cites W2910487490 @default.
- W3016283877 cites W2949332808 @default.
- W3016283877 cites W2950446586 @default.
- W3016283877 cites W2961348108 @default.
- W3016283877 cites W2967059818 @default.
- W3016283877 cites W2990395719 @default.
- W3016283877 cites W4246604100 @default.
- W3016283877 doi "https://doi.org/10.1101/2020.04.17.046052" @default.
- W3016283877 hasPublicationYear "2020" @default.
- W3016283877 type Work @default.
- W3016283877 sameAs 3016283877 @default.
- W3016283877 citedByCount "2" @default.
- W3016283877 countsByYear W30162838772020 @default.
- W3016283877 countsByYear W30162838772021 @default.
- W3016283877 crossrefType "posted-content" @default.
- W3016283877 hasAuthorship W3016283877A5000275701 @default.
- W3016283877 hasAuthorship W3016283877A5007394641 @default.
- W3016283877 hasAuthorship W3016283877A5013597002 @default.
- W3016283877 hasAuthorship W3016283877A5021505844 @default.
- W3016283877 hasAuthorship W3016283877A5022956981 @default.
- W3016283877 hasAuthorship W3016283877A5028046698 @default.
- W3016283877 hasAuthorship W3016283877A5050218156 @default.
- W3016283877 hasAuthorship W3016283877A5072133775 @default.
- W3016283877 hasAuthorship W3016283877A5073493153 @default.
- W3016283877 hasAuthorship W3016283877A5078242769 @default.
- W3016283877 hasAuthorship W3016283877A5085233233 @default.
- W3016283877 hasBestOaLocation W30162838771 @default.
- W3016283877 hasConcept C104317684 @default.
- W3016283877 hasConcept C111936080 @default.
- W3016283877 hasConcept C127716648 @default.