Matches in SemOpenAlex for { <https://semopenalex.org/work/W3018498129> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3018498129 abstract "Glycation of proteins and subsequent production of advanced glycation end products (AGEs) is a major contributor to the pathophysiology of diabetes. The objective of the present study was to compare the glycation of avian and human serum albumin to elucidate the mechanisms by which protein glycation in birds is prevented in the presence of naturally high plasma glucose concentrations. Solutions of purified chicken and human serum albumin (CSA and HSA) were prepared with four different glucose concentrations (0, 5.56, 11.1, and 22.2mM) and incubated at three temperatures (37.0, 39.8, and 41.4°C) for seven days. The solutions were sampled on Days 0, 3, and 7 and analyzed by liquid chromatography-electrospray ionization-mass spectrometry for the presence of glycated albumin. Four-way repeated measures ANOVA (p=0.032) indicate that all independent variables (albumin type, glucose concentration, temperature and time) interacted to affect the degree of glycation. With increasing glucose concentration, the glycation of both HSA and CSA increased with time at all temperatures. In addition, HSA was glycated to a greater extent than CSA at the two higher glucose concentrations for all temperature conditions. Glycation was elevated with increasing temperatures for HSA but not CSA. The results suggest an inherent difference between human and chicken albumin that contributes to the observed differences in glycation. Further research is needed to characterize this inherent difference in an effort to elucidate mechanisms by which avian plasma protein is glycated to a lesser degree than that of mammals (humans)." @default.
- W3018498129 created "2020-05-01" @default.
- W3018498129 creator A5006733880 @default.
- W3018498129 creator A5033337485 @default.
- W3018498129 creator A5060743715 @default.
- W3018498129 creator A5085207276 @default.
- W3018498129 date "2017-01-01" @default.
- W3018498129 modified "2023-09-26" @default.
- W3018498129 title "Chicken albumin exhibits natural resistance to glycation Part B Biochemistry & molecular biology" @default.
- W3018498129 hasPublicationYear "2017" @default.
- W3018498129 type Work @default.
- W3018498129 sameAs 3018498129 @default.
- W3018498129 citedByCount "0" @default.
- W3018498129 crossrefType "journal-article" @default.
- W3018498129 hasAuthorship W3018498129A5006733880 @default.
- W3018498129 hasAuthorship W3018498129A5033337485 @default.
- W3018498129 hasAuthorship W3018498129A5060743715 @default.
- W3018498129 hasAuthorship W3018498129A5085207276 @default.
- W3018498129 hasConcept C126322002 @default.
- W3018498129 hasConcept C134018914 @default.
- W3018498129 hasConcept C146543888 @default.
- W3018498129 hasConcept C147990577 @default.
- W3018498129 hasConcept C165220095 @default.
- W3018498129 hasConcept C165616093 @default.
- W3018498129 hasConcept C170493617 @default.
- W3018498129 hasConcept C185592680 @default.
- W3018498129 hasConcept C2776125364 @default.
- W3018498129 hasConcept C2778597219 @default.
- W3018498129 hasConcept C2780963292 @default.
- W3018498129 hasConcept C55493867 @default.
- W3018498129 hasConcept C555293320 @default.
- W3018498129 hasConcept C71924100 @default.
- W3018498129 hasConcept C86803240 @default.
- W3018498129 hasConceptScore W3018498129C126322002 @default.
- W3018498129 hasConceptScore W3018498129C134018914 @default.
- W3018498129 hasConceptScore W3018498129C146543888 @default.
- W3018498129 hasConceptScore W3018498129C147990577 @default.
- W3018498129 hasConceptScore W3018498129C165220095 @default.
- W3018498129 hasConceptScore W3018498129C165616093 @default.
- W3018498129 hasConceptScore W3018498129C170493617 @default.
- W3018498129 hasConceptScore W3018498129C185592680 @default.
- W3018498129 hasConceptScore W3018498129C2776125364 @default.
- W3018498129 hasConceptScore W3018498129C2778597219 @default.
- W3018498129 hasConceptScore W3018498129C2780963292 @default.
- W3018498129 hasConceptScore W3018498129C55493867 @default.
- W3018498129 hasConceptScore W3018498129C555293320 @default.
- W3018498129 hasConceptScore W3018498129C71924100 @default.
- W3018498129 hasConceptScore W3018498129C86803240 @default.
- W3018498129 hasLocation W30184981291 @default.
- W3018498129 hasOpenAccess W3018498129 @default.
- W3018498129 hasPrimaryLocation W30184981291 @default.
- W3018498129 hasRelatedWork W1498823122 @default.
- W3018498129 hasRelatedWork W1973980078 @default.
- W3018498129 hasRelatedWork W2000702607 @default.
- W3018498129 hasRelatedWork W2001437283 @default.
- W3018498129 hasRelatedWork W2021092893 @default.
- W3018498129 hasRelatedWork W2021280058 @default.
- W3018498129 hasRelatedWork W2034715178 @default.
- W3018498129 hasRelatedWork W2034794069 @default.
- W3018498129 hasRelatedWork W2041574464 @default.
- W3018498129 hasRelatedWork W2074738591 @default.
- W3018498129 hasRelatedWork W2094404939 @default.
- W3018498129 hasRelatedWork W2095211708 @default.
- W3018498129 hasRelatedWork W2132438862 @default.
- W3018498129 hasRelatedWork W2136522112 @default.
- W3018498129 hasRelatedWork W2535158291 @default.
- W3018498129 hasRelatedWork W2735121832 @default.
- W3018498129 hasRelatedWork W3213977137 @default.
- W3018498129 hasRelatedWork W372595529 @default.
- W3018498129 hasRelatedWork W391090057 @default.
- W3018498129 hasRelatedWork W70612297 @default.
- W3018498129 isParatext "false" @default.
- W3018498129 isRetracted "false" @default.
- W3018498129 magId "3018498129" @default.
- W3018498129 workType "article" @default.