FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019678345> ?p ?o ?g. }

• W3019678345 abstract "d ‐amino acid oxidase (DAO) is a peroxisomal enzyme that catalyzes the oxidative deamination of several neutral and basic d ‐amino acids to their corresponding α ‐keto acids. In most mammalian species studied, high DAO activity is found in the kidney, liver, brain and polymorphonuclear leukocytes, and its main function is to maintain low circulating d ‐amino acid levels. DAO expression and activity have been associated with acute and chronic kidney diseases and with several pathologies related to N ‐methyl‐ d ‐aspartate (NMDA) receptor hypo/hyper‐function; however, its precise role is not completely understood. In the present study we show that DAO activity can be detected in vivo in the rat kidney using hyperpolarized d ‐[1‐ 13 C]alanine. Following a bolus of hyperpolarized d ‐alanine, accumulation of pyruvate, lactate and bicarbonate was observed only when DAO activity was not inhibited. The measured lactate‐to‐ d ‐alanine ratio was comparable to the values measured when the l ‐enantiomer was injected. Metabolites downstream of DAO were not observed when scanning the liver and brain. The conversion of hyperpolarized d ‐[1‐ 13 C]alanine to lactate and pyruvate was detected in blood ex vivo , and lactate and bicarbonate were detected on scanning the blood pool in the heart in vivo ; however, the bicarbonate‐to‐ d ‐alanine ratio was significantly lower compared with the kidney. These results demonstrate that the specific metabolism of the two enantiomers of hyperpolarized [1‐ 13 C]alanine in the kidney and in the blood can be distinguished, underscoring the potential of d ‐[1‐ 13 C]alanine as a probe of d ‐amino acid metabolism." @default.
• W3019678345 created "2020-05-01" @default.
• W3019678345 creator A5015200150 @default.
• W3019678345 creator A5029409294 @default.
• W3019678345 creator A5045354243 @default.
• W3019678345 date "2020-04-23" @default.
• W3019678345 modified "2023-10-01" @default.
• W3019678345 title "<i>In vivo</i>detection of<scp>d</scp>‐amino acid oxidase with hyperpolarized<scp>d</scp>‐[1‐¹³C]alanine" @default.
• W3019678345 cites W1486774900 @default.
• W3019678345 cites W1559739851 @default.
• W3019678345 cites W1601614334 @default.
• W3019678345 cites W1794112849 @default.
• W3019678345 cites W1971964419 @default.
• W3019678345 cites W1977187301 @default.
• W3019678345 cites W1995428934 @default.
• W3019678345 cites W1999012342 @default.
• W3019678345 cites W2023208818 @default.
• W3019678345 cites W2027394958 @default.
• W3019678345 cites W2031158222 @default.
• W3019678345 cites W2042538105 @default.
• W3019678345 cites W2043232646 @default.
• W3019678345 cites W2044397707 @default.
• W3019678345 cites W2044977347 @default.
• W3019678345 cites W2055715074 @default.
• W3019678345 cites W2059900570 @default.
• W3019678345 cites W2062298313 @default.
• W3019678345 cites W2069760452 @default.
• W3019678345 cites W2081588254 @default.
• W3019678345 cites W2081868313 @default.
• W3019678345 cites W2087538859 @default.
• W3019678345 cites W2088673763 @default.
• W3019678345 cites W2090927900 @default.
• W3019678345 cites W2098992621 @default.
• W3019678345 cites W2129385697 @default.
• W3019678345 cites W2134655796 @default.
• W3019678345 cites W2135997515 @default.
• W3019678345 cites W2162480236 @default.
• W3019678345 cites W2434573689 @default.
• W3019678345 cites W2593235852 @default.
• W3019678345 cites W2745257624 @default.
• W3019678345 cites W2765374660 @default.
• W3019678345 cites W2767683865 @default.
• W3019678345 cites W2790965678 @default.
• W3019678345 cites W2953085192 @default.
• W3019678345 cites W3004553650 @default.
• W3019678345 cites W4243239484 @default.
• W3019678345 doi "https://doi.org/10.1002/nbm.4303" @default.
• W3019678345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32325540" @default.
• W3019678345 hasPublicationYear "2020" @default.
• W3019678345 type Work @default.
• W3019678345 sameAs 3019678345 @default.
• W3019678345 citedByCount "1" @default.
• W3019678345 countsByYear W30196783452021 @default.
• W3019678345 crossrefType "journal-article" @default.
• W3019678345 hasAuthorship W3019678345A5015200150 @default.
• W3019678345 hasAuthorship W3019678345A5029409294 @default.
• W3019678345 hasAuthorship W3019678345A5045354243 @default.
• W3019678345 hasConcept C150903083 @default.
• W3019678345 hasConcept C178790620 @default.
• W3019678345 hasConcept C181199279 @default.
• W3019678345 hasConcept C185592680 @default.
• W3019678345 hasConcept C197974221 @default.
• W3019678345 hasConcept C207001950 @default.
• W3019678345 hasConcept C2778239910 @default.
• W3019678345 hasConcept C2779856020 @default.
• W3019678345 hasConcept C2781112554 @default.
• W3019678345 hasConcept C38485361 @default.
• W3019678345 hasConcept C515207424 @default.
• W3019678345 hasConcept C55493867 @default.
• W3019678345 hasConcept C86803240 @default.
• W3019678345 hasConceptScore W3019678345C150903083 @default.
• W3019678345 hasConceptScore W3019678345C178790620 @default.
• W3019678345 hasConceptScore W3019678345C181199279 @default.
• W3019678345 hasConceptScore W3019678345C185592680 @default.
• W3019678345 hasConceptScore W3019678345C197974221 @default.
• W3019678345 hasConceptScore W3019678345C207001950 @default.
• W3019678345 hasConceptScore W3019678345C2778239910 @default.
• W3019678345 hasConceptScore W3019678345C2779856020 @default.
• W3019678345 hasConceptScore W3019678345C2781112554 @default.
• W3019678345 hasConceptScore W3019678345C38485361 @default.
• W3019678345 hasConceptScore W3019678345C515207424 @default.
• W3019678345 hasConceptScore W3019678345C55493867 @default.
• W3019678345 hasConceptScore W3019678345C86803240 @default.
• W3019678345 hasIssue "7" @default.
• W3019678345 hasLocation W30196783451 @default.
• W3019678345 hasOpenAccess W3019678345 @default.
• W3019678345 hasPrimaryLocation W30196783451 @default.
• W3019678345 hasRelatedWork W1970703688 @default.
• W3019678345 hasRelatedWork W1983192825 @default.
• W3019678345 hasRelatedWork W2023130986 @default.
• W3019678345 hasRelatedWork W2024862657 @default.
• W3019678345 hasRelatedWork W2046498090 @default.
• W3019678345 hasRelatedWork W2051826279 @default.
• W3019678345 hasRelatedWork W2060392955 @default.
• W3019678345 hasRelatedWork W2126863462 @default.
• W3019678345 hasRelatedWork W2772607035 @default.
• W3019678345 hasRelatedWork W39092003 @default.
• W3019678345 hasVolume "33" @default.
• W3019678345 isParatext "false" @default.
• W3019678345 isRetracted "false" @default.

• next