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- W3030455380 abstract "Objective To explore the association of the expressions of MMP-9 and MMP-14 in breast cancer with lymph node metastasis and lymphangiogenesis. Methods The expression levels of MMP-9 and MMP-14 were detected by hand-made tissue microarray and immunohistochemistry in benign breast diseases and breast cancer. The number of lymphatic vessels marked with D2-40 mark was counted. Results The expressions of MMP-9 and MMP-14 differed significantly between benign breast disease group and breast cancer group ( P＜ 0.01 ). There were significant difference in the expressions of MMP-9 and MMP-14 based on tumor size, stages of ductal carcinoma, and lymph node metastasis ( P＜ 0.01 ). The lymphatic vessel density ( LVD )was significantly higher in the paracancerous areas than in the central areasand the benign breast tissues ( P＜0.01 ). There were significant differences between the expressions of MMP-9 and MMP-14 and LVD in the paracancerous areas (P ＜ 0.01 ). Conclusions MMP-9 and MMP-14 are positively related with lymphangiogenesis and lymph node metastasis.Key words: Breast cancer, Lymphatic vessel density; Lymphangiogenesis; Lymph node metastasis; Matrix metalloproteinases; Tissue chip" @default.
- W3030455380 created "2020-06-05" @default.
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- W3030455380 date "2011-08-01" @default.
- W3030455380 modified "2023-09-24" @default.
- W3030455380 title "Association of MMP-9 and MMP-14 with lymphangiogenesis and lymph node metastasis in breast cancer" @default.
- W3030455380 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2011.15.007" @default.
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