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- W3031286048 abstract "目的 探讨MMP 2、MMP 9在非小细胞肺癌组织中的表达及其与临床病理特征的关系.方法用链菌素生物素蛋白-过氧化物酶免疫组织化学法(SP法)检测83例手术切除的NSCLC组织及其交界区组织和24例正常肺组织中MMP 2、MMP 9的表达,分析二者在肿瘤组织中的过表达与NSCLC的临床病理特征的关系.结果 MMP 2、MMP 9主要表达于肿瘤细胞的胞浆,在癌旁交界区组织也有表达,肿瘤组织的过表达率显著高于交界区(p<0.005),在正常组织中无过表达;二者的过表达与肿瘤类型、病理分级、性别、年龄、吸烟史无明显关系;MMP 2在肿瘤组织的过表达率与淋巴结转移状态及临床分期有关(p<0.05).结论 MMP 2、MMP 9都参与了NSCLC发生发展过程,并且可能对肿瘤的发生发展有促进作用,MMP 2与淋巴结转移和临床分期密切相关。" @default.
- W3031286048 created "2020-06-05" @default.
- W3031286048 date "2005-06-01" @default.
- W3031286048 modified "2023-09-27" @default.
- W3031286048 title "The Relationship between MMP 2,MMP 9 Expression and Clinic Pathological Features in Non-small-cell Lung Carcinoma" @default.
- W3031286048 doi "https://doi.org/10.3760/cma.j.issn.1008-634x.2005.03.004" @default.
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