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- W3031732478 abstract "Objective To investigate effect of the copper (Ⅰ) complexes with coumarin derivatives (coumarin-copper drugs) on lung cancer cell (A549 cell line) in vivo and vitro and its mechanism of action.Methods A549 cells were treated with different concentrations of the coumarin-copper drugs,MTT assay was performed to determine cell ratio.Cell apoptosis was detected by Annexin V/PI flow cytometry.Western blot was performed to evaluate the protein expression of caspase-3.The subcutaneous transplantable tumor model of A549 cell in nude mice was established.The nude mice in each group received corresponding treated.The growth curves of the tumor were drawn and the tumor growth inhibition rates were calculated.The apoptosis index of subcutaneously transplanted tumor cells was served by TUNEL.Results Coumarin-copper drugs effectively inhibited the proliferation of A549 in a dose-and-time dependent manner,and the IC50 was 2.0 μmol/L.Coumarin-copper drugs could induce the apoptosis of A549 cells in a dose dependent way (P ＜ 0.05),which was accompany with upregulation of caspase-3.Coumarin copper drugs effectively inhibited the growth of A549 tumor in a dose dependent manner,kept company with the apoptosis index of A549 tumor (P ＜0.05).Conclusions Coumarin copper drugs may inhibit the proliferation of A549 cells through inducing cell apoptosis,which should be related to the up-regulation of caspase-3.Key words: Coumarin-copper drugs; Lung cancer ; Apoptosis ; Caspase-3" @default.
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- W3031732478 date "2013-11-20" @default.
- W3031732478 modified "2023-09-23" @default.
- W3031732478 title "Effect and their mechanism of action of copper(II) complexes with coumarin derivatives on lung cancer in vivo and vitro" @default.
- W3031732478 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2013.022.003" @default.
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