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- W3032051625 abstract "Malignant tumors have been seriously threatening human’s life and health.Genetically engineered T cells can reprogram antigen specificity and functions.Chimeric antigen receptor (CAR)-T cells, also called as the CAR-T cells, is a kind of innovative adoptive therapy based on receptor synthesis.It carries specific antigen receptors and immunoregulatory co-stimulatory molecules independent of the major histocompatibility complex (MHC) to achieve efficient response to tumor targets.CAR-T cell therapy is effective in the treatment of hematological tumors, especially CD19-positive leukemia.However, this therapy still faces some obstacles in the treatment of solid malignant tumors.Targeted to overcome these problems, the development of new CAR-T cell therapy strategies for solid tumors is highly anticipated and has promising prospects.Key words: Chimeric antigen receptor T cells; Solid tumors; Adoptive T cell transfer" @default.
- W3032051625 created "2020-06-05" @default.
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- W3032051625 date "2019-01-05" @default.
- W3032051625 modified "2023-09-24" @default.
- W3032051625 title "The opportunity and challenge of genetically engineered CAR-T cells in the treatment of solid tumors" @default.
- W3032051625 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2019.01.019" @default.
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