Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037001487> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3037001487 abstract "Introduction A series of transcription factors have been profiled in ischaemic stroke. Forkhead box protein O 3a (FoxO3a), which belongs to the family of transcription factors, is characterised by a forkhead DNA-binding domain. However, the role of FoxO3a and circFoxO3, which is encoded from FOXO3 gene in stroke, remains unelucidated. Material and methods A rat model of middle cerebral artery occlusion (MCAO)/reperfusion was applied, and rat neuroblastoma B35 cells were treated with cobalt chloride to mimic cellular hypoxia in vitro. FoxO3a (or circFoxO3a) was manipulated to assess the infarction volume and apoptotic proteins. Results Brain infarction was enlarged in ischaemia/reperfusion compared with simple ischaemia treatment. The protein level of FoxO3a increased significantly in MCAO and subsequently decreased following reperfusion. Increased FoxO3a expression was also found in CoCl2 treatment at 24 h and 48 h. Downregulation of FoxO3a significantly promoted apoptosis, while upregulation of FoxO3a reduced apoptosis. Further biochemical analysis demonstrated that protein expression level of caspase-3, caspase-9, and Bax were upregulated following FoxO3a inhibition but downregulated following FoxO3a overexpression. Moreover, upregulated FoxO3a level was consistent with enhanced circFoxO3 expression both in vivo and in vitro. Conclusions Both FoxO3a and circFoxO3 are upregulated in ischaemic stroke, which associates with the apoptosis pathway. Hence, FoxO3a and circFoxO3 might be protective factors against hypoxia/ischaemia-induced neuronal damage." @default.
- W3037001487 created "2020-07-02" @default.
- W3037001487 creator A5005220135 @default.
- W3037001487 creator A5018638245 @default.
- W3037001487 creator A5042523440 @default.
- W3037001487 creator A5043730029 @default.
- W3037001487 creator A5055151897 @default.
- W3037001487 creator A5055555472 @default.
- W3037001487 creator A5064317688 @default.
- W3037001487 creator A5071210133 @default.
- W3037001487 creator A5080842533 @default.
- W3037001487 creator A5081876745 @default.
- W3037001487 creator A5082281032 @default.
- W3037001487 date "2020-06-23" @default.
- W3037001487 modified "2023-09-23" @default.
- W3037001487 title "Upregulation of Foxo3a protects neurons against hypoxia-ischaemia injury" @default.
- W3037001487 doi "https://doi.org/10.5114/aoms.2020.96620" @default.
- W3037001487 hasPublicationYear "2020" @default.
- W3037001487 type Work @default.
- W3037001487 sameAs 3037001487 @default.
- W3037001487 citedByCount "0" @default.
- W3037001487 crossrefType "journal-article" @default.
- W3037001487 hasAuthorship W3037001487A5005220135 @default.
- W3037001487 hasAuthorship W3037001487A5018638245 @default.
- W3037001487 hasAuthorship W3037001487A5042523440 @default.
- W3037001487 hasAuthorship W3037001487A5043730029 @default.
- W3037001487 hasAuthorship W3037001487A5055151897 @default.
- W3037001487 hasAuthorship W3037001487A5055555472 @default.
- W3037001487 hasAuthorship W3037001487A5064317688 @default.
- W3037001487 hasAuthorship W3037001487A5071210133 @default.
- W3037001487 hasAuthorship W3037001487A5080842533 @default.
- W3037001487 hasAuthorship W3037001487A5081876745 @default.
- W3037001487 hasAuthorship W3037001487A5082281032 @default.
- W3037001487 hasBestOaLocation W30370014871 @default.
- W3037001487 hasConcept C104317684 @default.
- W3037001487 hasConcept C126322002 @default.
- W3037001487 hasConcept C127561419 @default.
- W3037001487 hasConcept C168003608 @default.
- W3037001487 hasConcept C178790620 @default.
- W3037001487 hasConcept C185592680 @default.
- W3037001487 hasConcept C190283241 @default.
- W3037001487 hasConcept C540031477 @default.
- W3037001487 hasConcept C541997718 @default.
- W3037001487 hasConcept C55493867 @default.
- W3037001487 hasConcept C71924100 @default.
- W3037001487 hasConcept C7836513 @default.
- W3037001487 hasConcept C86339819 @default.
- W3037001487 hasConcept C86803240 @default.
- W3037001487 hasConcept C95444343 @default.
- W3037001487 hasConceptScore W3037001487C104317684 @default.
- W3037001487 hasConceptScore W3037001487C126322002 @default.
- W3037001487 hasConceptScore W3037001487C127561419 @default.
- W3037001487 hasConceptScore W3037001487C168003608 @default.
- W3037001487 hasConceptScore W3037001487C178790620 @default.
- W3037001487 hasConceptScore W3037001487C185592680 @default.
- W3037001487 hasConceptScore W3037001487C190283241 @default.
- W3037001487 hasConceptScore W3037001487C540031477 @default.
- W3037001487 hasConceptScore W3037001487C541997718 @default.
- W3037001487 hasConceptScore W3037001487C55493867 @default.
- W3037001487 hasConceptScore W3037001487C71924100 @default.
- W3037001487 hasConceptScore W3037001487C7836513 @default.
- W3037001487 hasConceptScore W3037001487C86339819 @default.
- W3037001487 hasConceptScore W3037001487C86803240 @default.
- W3037001487 hasConceptScore W3037001487C95444343 @default.
- W3037001487 hasLocation W30370014871 @default.
- W3037001487 hasOpenAccess W3037001487 @default.
- W3037001487 hasPrimaryLocation W30370014871 @default.
- W3037001487 hasRelatedWork W12142650 @default.
- W3037001487 hasRelatedWork W14142049 @default.
- W3037001487 hasRelatedWork W14301894 @default.
- W3037001487 hasRelatedWork W15614033 @default.
- W3037001487 hasRelatedWork W19928713 @default.
- W3037001487 hasRelatedWork W2962824 @default.
- W3037001487 hasRelatedWork W8472413 @default.
- W3037001487 hasRelatedWork W12500765 @default.
- W3037001487 hasRelatedWork W16375900 @default.
- W3037001487 hasRelatedWork W2557491 @default.
- W3037001487 isParatext "false" @default.
- W3037001487 isRetracted "false" @default.
- W3037001487 magId "3037001487" @default.
- W3037001487 workType "article" @default.