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- W3040995300 endingPage "2037" @default.
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- W3040995300 abstract "Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil; ω3PL-H) and triacylglycerols (ω3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of ω3TG or ω3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the ω3PL-H and ω3TG groups, respectively. Compared to HFD mice, ω3PL-H but not ω3TG animals had lower body weight gain (−40%), mesenteric adipose tissue (−43%), and hepatic lipid content (−64%). The highest number and expression level of regulated intestinal genes was observed in ω3PL-H mice. The expression of FA ω-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA β-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in ω3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice." @default.
- W3040995300 created "2020-07-16" @default.
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- W3040995300 date "2020-07-09" @default.
- W3040995300 modified "2023-10-17" @default.
- W3040995300 title "Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice" @default.
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- W3040995300 doi "https://doi.org/10.3390/nu12072037" @default.
- W3040995300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7400938" @default.
- W3040995300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32660007" @default.
- W3040995300 hasPublicationYear "2020" @default.
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