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- W3042328539 abstract "The aim of the study is identification of features of Achilles tendon healing in the conditions of auto-transplantation of the cellular element, reflecting the regenerative activity of stromal-vascular fraction. Modern regenerative treatment methods for animal with tendon injuries involve stromal-vascular cells application of adipose tissue. They represent cell pool with high plasticity, proliferative activity, and ability to secrete multiple angiogenic factors. However, there is no data on morphological and morphometric regenerative equivalents of their use in case of tendon ligaments injury. Micro morphometrical indicators are presented that substantiate the effectiveness of using autologous cellular elements in case of Achilles tendon injury. The influence of stromal-vascular fraction from rat adipose tissue on regenerative process during healing of an induced tendon tissue defect was evaluated which lead to an increase in the thickness of bundles of the first and the second orders in the experimental group, significant differences in comparison with the control of the fibroblastic cell pool, and the number of blood capillaries of these animals. Based on the positive data of the autologous cell pool on the regenerative ability of the Achilles tendon, its practicability for veterinary medicine was scientifically justified. The experimental model of the study is a fancy rat (n=20). Achilles tendon was the research material. A complex methodological approach was used, including experimental modeling, micro morphological studies, micro morphometry, and statistical data processing. It was revealed that experimental animals injected with stromal-vascular fraction, micro morphometric transformations of connective tissue were detected, aimed at thickening of bundles of the first and second orders, the transition of fibroblasts to structured and ordered fibrocytes (tenocytes), acceleration of collagenogenesis and vascularization enhancement." @default.
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- W3042328539 date "2020-07-15" @default.
- W3042328539 modified "2023-09-23" @default.
- W3042328539 title "FEATURES OF REPARATIVE REGENERATION OF ACHILLES TENDON IN THE CONDITIONS OF AUTOLOGOUS TRANSPLANTATION OF CELL POOL" @default.
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- W3042328539 doi "https://doi.org/10.17816/1997-3225.20205346-50" @default.
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