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• W3042840492 abstract "[b]BACKGROUND[/b] Insulin sensitivity and inflammation can be affected by juxtaposition with another zinc finger gene 1 ([i]JAZF1[/i]), but its precise role in chronic inflammation is unclear. In this study, [i]JAZF1[/i]-overexpression adenovirus plasmids were transfected into macrophages, CD4⁺ T cells, and C57BL/6J mice to assess the role of [i]JAZF1 [/i]in chronic inflammation. [b]MATERIAL AND METHODS[/b] [i]JAZF1 [/i]was cloned into an adenovirus skeleton plasmid and transfected in HEK293 cells to package and enrich the virus particles. [i]In vitro[/i], the [i]JAZF1[/i] overexpression adenovirus vector (PAD-JAZF1) was cultured with peritoneal macrophages and peripheral blood CD4⁺ T cells of C57BL/6J mice, and samples were evaluated using flow cytometry. [i]In vivo[/i], PAD-JAZF1 was introduced into C57BL/6J mice, and livers were collected to evaluate factors related to inflammation by hematoxylin & eosin and immunohistochemical staining. [b]RESULTS[/b] [i]In vitro[/i], PAD-JAZF1 decreased total macrophages, CD11c⁺ macrophages, and the secretion of proinflammatory cytokines, but increased CD206⁺ macrophages. It also decreased total CD4⁺T cells, active T cells, memory T cells, and the secretion of IL-6, IL-10, and IFN-γ, but increased Treg cells and restrictive T cells. [i]In vivo[/i], compared to those in the control group transfected with the adenovirus skeleton vector, mice transfected with the PAD-JAZF1 recombinant adenovirus had fewer CD11c⁺ ATMs and CD4⁺ T cells, lower levels of TNF-alpha and IL-6, and higher IL-10 concentrations in the liver. [b]CONCLUSIONS[/b] These findings indicate that [i]JAZF1 [/i]limits chronic inflammation by reducing macrophage and CD4⁺T cell populations, altering subtype differentiation, and regulating the secretion of immune-related factors." @default.
• W3042840492 created "2020-07-23" @default.
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• W3042840492 date "2020-07-13" @default.
• W3042840492 modified "2023-10-18" @default.
• W3042840492 title "Effects of Adenovirus-Mediated Overexpression of JAZF1 on Chronic Inflammation: An In Vitro and In Vivo Study" @default.
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• W3042840492 doi "https://doi.org/10.12659/msmbr.924124" @default.
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