Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043682021> ?p ?o ?g. }
- W3043682021 endingPage "2235" @default.
- W3043682021 startingPage "2224" @default.
- W3043682021 abstract "Abstract Diabetes-associated periodontitis (DP) aggravates diabetic complications and increases mortality from diabetes. DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult. In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP. Moreover, inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation. Furthermore, bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium. This finding provides a basis for the development of an effective therapeutic approach for treating DP." @default.
- W3043682021 created "2020-07-23" @default.
- W3043682021 creator A5006690496 @default.
- W3043682021 creator A5017082027 @default.
- W3043682021 creator A5028949606 @default.
- W3043682021 creator A5041358497 @default.
- W3043682021 creator A5049689892 @default.
- W3043682021 creator A5060856800 @default.
- W3043682021 creator A5074912922 @default.
- W3043682021 creator A5084600019 @default.
- W3043682021 creator A5089725662 @default.
- W3043682021 date "2020-07-16" @default.
- W3043682021 modified "2023-10-15" @default.
- W3043682021 title "Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties" @default.
- W3043682021 cites W1512020104 @default.
- W3043682021 cites W1753749227 @default.
- W3043682021 cites W1962263847 @default.
- W3043682021 cites W1969262319 @default.
- W3043682021 cites W1977274830 @default.
- W3043682021 cites W1990974422 @default.
- W3043682021 cites W2016459074 @default.
- W3043682021 cites W2025763283 @default.
- W3043682021 cites W2051030481 @default.
- W3043682021 cites W2055166353 @default.
- W3043682021 cites W2056598170 @default.
- W3043682021 cites W2062764413 @default.
- W3043682021 cites W2066151306 @default.
- W3043682021 cites W2067867027 @default.
- W3043682021 cites W2090698350 @default.
- W3043682021 cites W2093930780 @default.
- W3043682021 cites W2110385952 @default.
- W3043682021 cites W2123754949 @default.
- W3043682021 cites W2130005272 @default.
- W3043682021 cites W2130787277 @default.
- W3043682021 cites W2139655860 @default.
- W3043682021 cites W2145093771 @default.
- W3043682021 cites W2145461802 @default.
- W3043682021 cites W2153960708 @default.
- W3043682021 cites W2159169229 @default.
- W3043682021 cites W2234646866 @default.
- W3043682021 cites W2237837447 @default.
- W3043682021 cites W2404495146 @default.
- W3043682021 cites W2407173381 @default.
- W3043682021 cites W2549669347 @default.
- W3043682021 cites W2566792041 @default.
- W3043682021 cites W2589030468 @default.
- W3043682021 cites W2614841288 @default.
- W3043682021 cites W2760098333 @default.
- W3043682021 cites W2767984094 @default.
- W3043682021 cites W2787735037 @default.
- W3043682021 cites W2789287894 @default.
- W3043682021 cites W2789727821 @default.
- W3043682021 cites W2796965506 @default.
- W3043682021 cites W2802406389 @default.
- W3043682021 cites W2890694022 @default.
- W3043682021 cites W2891150895 @default.
- W3043682021 cites W2897945399 @default.
- W3043682021 cites W2898914603 @default.
- W3043682021 cites W2909900715 @default.
- W3043682021 cites W2911886724 @default.
- W3043682021 cites W2912555658 @default.
- W3043682021 cites W2945953423 @default.
- W3043682021 cites W2963181696 @default.
- W3043682021 cites W2972338204 @default.
- W3043682021 cites W2973278746 @default.
- W3043682021 cites W2975862998 @default.
- W3043682021 cites W2982346128 @default.
- W3043682021 cites W2994797447 @default.
- W3043682021 cites W3003163062 @default.
- W3043682021 cites W3010018464 @default.
- W3043682021 cites W3023565986 @default.
- W3043682021 cites W4211223324 @default.
- W3043682021 doi "https://doi.org/10.1038/s41423-020-0500-1" @default.
- W3043682021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8429574" @default.
- W3043682021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32678310" @default.
- W3043682021 hasPublicationYear "2020" @default.
- W3043682021 type Work @default.
- W3043682021 sameAs 3043682021 @default.
- W3043682021 citedByCount "26" @default.
- W3043682021 countsByYear W30436820212021 @default.
- W3043682021 countsByYear W30436820212022 @default.
- W3043682021 countsByYear W30436820212023 @default.
- W3043682021 crossrefType "journal-article" @default.
- W3043682021 hasAuthorship W3043682021A5006690496 @default.
- W3043682021 hasAuthorship W3043682021A5017082027 @default.
- W3043682021 hasAuthorship W3043682021A5028949606 @default.
- W3043682021 hasAuthorship W3043682021A5041358497 @default.
- W3043682021 hasAuthorship W3043682021A5049689892 @default.
- W3043682021 hasAuthorship W3043682021A5060856800 @default.
- W3043682021 hasAuthorship W3043682021A5074912922 @default.
- W3043682021 hasAuthorship W3043682021A5084600019 @default.
- W3043682021 hasAuthorship W3043682021A5089725662 @default.
- W3043682021 hasBestOaLocation W30436820211 @default.
- W3043682021 hasConcept C101666144 @default.
- W3043682021 hasConcept C126322002 @default.
- W3043682021 hasConcept C13373296 @default.
- W3043682021 hasConcept C134018914 @default.
- W3043682021 hasConcept C151279780 @default.