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• W3048649174 abstract "Abstract CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as an adhesion molecule to mediate a homophilic adhesion through the direct interactions between CD146 and itself is still lacking. Recent evidence revealed that CD146 is not merely an adhesion molecule, but also a cellular surface receptor of miscellaneous ligands, including some growth factors and extracellular matrixes. Through the bidirectional interactions with its ligands, CD146 is actively involved in numerous physiological and pathological processes of cells. Overexpression of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers, especially vascular and lymphatic metastasis. Thus, immunotherapy against CD146 would provide a promising strategy to inhibit metastasis, which accounts for the majority of cancer-associated deaths. Therefore, to deepen the understanding of CD146, we review the reports describing the newly identified ligands of CD146 and discuss the implications of these findings in establishing novel strategies for cancer therapy." @default.
• W3048649174 created "2020-08-18" @default.
• W3048649174 creator A5023277894 @default.
• W3048649174 creator A5043930366 @default.
• W3048649174 creator A5052753033 @default.
• W3048649174 creator A5071376462 @default.
• W3048649174 creator A5082196582 @default.
• W3048649174 creator A5088474365 @default.
• W3048649174 date "2020-08-11" @default.
• W3048649174 modified "2023-10-17" @default.
• W3048649174 title "CD146, from a melanoma cell adhesion molecule to a signaling receptor" @default.
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