FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082605101> ?p ?o ?g. }

• W3082605101 abstract "The development of allergic disease involves the production of IgE antibodies upon allergen exposure in a process called sensitization. IgE binds to receptors on the surface of mast cells and basophils, and subsequent allergen exposure leads to cross-linking of IgE antibodies and release of cell mediators that cause allergy symptoms. Although this process is quite well-understood, very little is known about the epitopes on the allergen recognized by IgE, despite the importance of the allergen-antibody interaction for the allergic response to occur. This review discusses efforts to analyze allergen-antibody interactions, from the original epitope mapping studies using linear peptides or recombinant allergen fragments, to more sophisticated technologies, such as X-ray crystallography and nuclear magnetic resonance. These state-of-the-art approaches, combined with site-directed mutagenesis, have led to the identification of conformational IgE epitopes. The first structures of an allergen (egg lysozyme) in complex with Fab fragments from IgG antibodies were determined in the 1980s. Since then, IgG has been used as surrogate for IgE, due to the difficulty of obtaining monoclonal IgE antibodies. Technical developments including phage display libraries have contributed to progress in epitope mapping thanks to the isolation of IgE antibody constructs from combinatorial libraries made from peripheral blood mononuclear cells of allergic donors. Most recently, single B cell antibody sequencing and human hybridomas are new breakthrough technologies for finally obtaining human IgE monoclonal antibodies, ideal for epitope mapping. The information on antigenic determinants will facilitate the design of hypoallergens for immunotherapy and the investigation of the fundamental mechanisms of the IgE response." @default.
• W3082605101 created "2020-09-08" @default.
• W3082605101 creator A5060470978 @default.
• W3082605101 creator A5065910573 @default.
• W3082605101 creator A5075248032 @default.
• W3082605101 date "2020-09-02" @default.
• W3082605101 modified "2023-10-16" @default.
• W3082605101 title "Structural Aspects of the Allergen-Antibody Interaction" @default.
• W3082605101 cites W1576807367 @default.
• W3082605101 cites W1759500815 @default.
• W3082605101 cites W1822277251 @default.
• W3082605101 cites W1869212877 @default.
• W3082605101 cites W1908511571 @default.
• W3082605101 cites W1949063151 @default.
• W3082605101 cites W1969500662 @default.
• W3082605101 cites W1969638854 @default.
• W3082605101 cites W1971323492 @default.
• W3082605101 cites W1976232165 @default.
• W3082605101 cites W1976454430 @default.
• W3082605101 cites W1978435585 @default.
• W3082605101 cites W1980975384 @default.
• W3082605101 cites W1982679430 @default.
• W3082605101 cites W1984997517 @default.
• W3082605101 cites W1990675281 @default.
• W3082605101 cites W1997851414 @default.
• W3082605101 cites W1999265751 @default.
• W3082605101 cites W2001803927 @default.
• W3082605101 cites W2006239665 @default.
• W3082605101 cites W2007135331 @default.
• W3082605101 cites W2008653735 @default.
• W3082605101 cites W2011136801 @default.
• W3082605101 cites W2011754226 @default.
• W3082605101 cites W2015381090 @default.
• W3082605101 cites W2015772732 @default.
• W3082605101 cites W2016299219 @default.
• W3082605101 cites W2018423289 @default.
• W3082605101 cites W2018470704 @default.
• W3082605101 cites W2020225869 @default.
• W3082605101 cites W2031989831 @default.
• W3082605101 cites W2035503835 @default.
• W3082605101 cites W2036700653 @default.
• W3082605101 cites W2037042031 @default.
• W3082605101 cites W2038614347 @default.
• W3082605101 cites W2039531874 @default.
• W3082605101 cites W2044098466 @default.
• W3082605101 cites W2047695535 @default.
• W3082605101 cites W2050301072 @default.
• W3082605101 cites W2052222309 @default.
• W3082605101 cites W2055894134 @default.
• W3082605101 cites W2056236033 @default.
• W3082605101 cites W2057222401 @default.
• W3082605101 cites W2059435741 @default.
• W3082605101 cites W2063488334 @default.
• W3082605101 cites W2064811345 @default.
• W3082605101 cites W2070341074 @default.
• W3082605101 cites W2072691313 @default.
• W3082605101 cites W2072854137 @default.
• W3082605101 cites W2073995629 @default.
• W3082605101 cites W2074243782 @default.
• W3082605101 cites W2076576008 @default.
• W3082605101 cites W2077170670 @default.
• W3082605101 cites W2077910253 @default.
• W3082605101 cites W2084710184 @default.
• W3082605101 cites W2090383712 @default.
• W3082605101 cites W2091477384 @default.
• W3082605101 cites W2091565674 @default.
• W3082605101 cites W2092258950 @default.
• W3082605101 cites W2092564708 @default.
• W3082605101 cites W2092861806 @default.
• W3082605101 cites W2093607407 @default.
• W3082605101 cites W2094157366 @default.
• W3082605101 cites W2095553811 @default.
• W3082605101 cites W2095571234 @default.
• W3082605101 cites W2098036906 @default.
• W3082605101 cites W2098419338 @default.
• W3082605101 cites W2099672409 @default.
• W3082605101 cites W2104630883 @default.
• W3082605101 cites W2105431164 @default.
• W3082605101 cites W2107202459 @default.
• W3082605101 cites W2110036226 @default.
• W3082605101 cites W2116809392 @default.
• W3082605101 cites W2117764478 @default.
• W3082605101 cites W2120563269 @default.
• W3082605101 cites W2123363094 @default.
• W3082605101 cites W2125474282 @default.
• W3082605101 cites W2126683946 @default.
• W3082605101 cites W2126723568 @default.
• W3082605101 cites W2132514101 @default.
• W3082605101 cites W2138554472 @default.
• W3082605101 cites W2149800784 @default.
• W3082605101 cites W2151197219 @default.
• W3082605101 cites W2152257846 @default.
• W3082605101 cites W2153421006 @default.
• W3082605101 cites W2155228565 @default.
• W3082605101 cites W2155699741 @default.
• W3082605101 cites W2158347168 @default.
• W3082605101 cites W2158471735 @default.
• W3082605101 cites W2159905210 @default.
• W3082605101 cites W2160617979 @default.
• W3082605101 cites W2162895551 @default.

• next